Targeting Protein Serine/Threonine Phosphatases for Drug Development

被引：138

作者：

McConnell, Jamie L. ^{[1
]}

Wadzinski, Brian E. ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Pharmacol, Med Ctr, Sch Med, Nashville, TN 37232 USA

来源：

MOLECULAR PHARMACOLOGY | 2009年 / 75卷 / 06期

基金：

美国国家卫生研究院;

关键词：

NF-KAPPA-B; SPHINGOSINE 1-PHOSPHATE RECEPTORS; 2A SUBUNIT INTERACTION; STRUCTURE-BASED DESIGN; TUMOR-SUPPRESSOR PP2A; MAP KINASE PATHWAY; SMALL-T-ANTIGEN; ANTICANCER ACTIVITY; CATALYTIC SUBUNIT; NORCANTHARIDIN ANALOGS;

D O I：

10.1124/mol.108.053140

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

With the recent clinical success of drugs targeting protein kinase activity, drug discovery efforts are focusing on the role of reversible protein phosphorylation in disease states. The activity of protein phosphatases, enzymes that oppose protein kinases, can also be manipulated to alter cellular signaling for therapeutic benefits. In this review, we present protein serine/threonine phosphatases as viable therapeutic targets, discussing past successes, current challenges, and future strategies for modulating phosphatase activity.

引用

页码：1249 / 1261

页数：13

共 154 条

[1] Raf-1-associated protein phosphatase 2A as a positive regulator of kinase activation
Abraham, D
Podar, K
Pacher, M
Kubicek, M
Welzel, N
Hemmings, BA
Dilworth, SM
Mischak, H
Kolch, W
Baccarini, M
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (29) : 22300 - 22304
[2] Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes
Adams, DG
Coffee, RL
Zhang, H
Pelech, S
Strack, S
Wadzinski, BE
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (52) : 42644 - 42654
[3] The design, synthesis, and biological evaluation of analogues of the serine-threonine protein phosphatase 1 and 2A selective inhibitor microcystin LA: Rational modifications imparting PP1 selectivity
Aggen, JB
Humphrey, JM
Gauss, CM
Huang, HB
Nairn, AC
Chamberlain, AR
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 1999, 7 (03) : 543 - 564
[4] Protein phosphatase 2A regulatory subunit b56α associates with c-Myc and negatively regulates c-Myc accumulation
Arnold, HK
Sears, RC
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (07) : 2832 - 2844
[5] Involvement of PP2A in viral and cellular transformation
Arroyo, JD
Hahn, WC
[J]. ONCOGENE, 2005, 24 (52) : 7746 - 7755
[6] Optically active cantharidin analogues possessing selective inhibitory activity on Ser/Thr protein phosphatase 2B (calcineurin): Implications for the binding mode
Baba, Y
Hirukawa, N
Sodeoka, M
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2005, 13 (17) : 5164 - 5170
[7] Structure-based design of a highly selective catalytic site-directed inhibitor of Ser/Thr protein phosphatase 2B (calcineurin)
Baba, Y
Hirukawa, N
Tanohira, N
Sodeoka, M
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (32) : 9740 - 9749
[8] The structure and mechanism of protein phosphatases: Insights into catalysis and regulation
Barford, D
Das, AK
Egloff, MP
[J]. ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 1998, 27 : 133 - 164
[9] Immunophilins: for the love of proteins
Barik, S.
[J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 2006, 63 (24) : 2889 - 2900
[10] Kinase- and phosphatase-anchoring proteins: harnessing the dynamic duo
Bauman, AL
Scott, JD
[J]. NATURE CELL BIOLOGY, 2002, 4 (08) : E203 - E206

← 1 2 3 4 5 6 7 8 9 10 →