Analysis of difference in vivo effects of TCDD between c-src +/+ mice, c-src deficient, ∓ and -/-B6, 129-Srctm 1 sor mice and their wild-type littermates

被引：6

作者：

Dunlap, DY

Matsumura, F

机构：

[1] Univ Calif Davis, Dept Environm Toxicol, Davis, CA 95616 USA

[2] Univ Calif Davis, Environm Hlth Sci Ctr, Davis, CA 95616 USA

来源：

CHEMOSPHERE | 2000年 / 40卷 / 9-11期

关键词：

D O I：

10.1016/S0045-6535(99)00375-6

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Toxicities of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) were tested on two strains of c-src deficient B6, 129-Src(tm) (1) (sor) mice, c-src -/+ and c-src -/- and their matched wild-type littermates c-src +/+ mice along with another c-src +/+ mice, from the same genetic lineage, B6, 129-Fos (tm 1 Pa) mice. The most conspicuous effect of c-src deficiency on the toxicity of TCDD appears to be the reduced hepatotoxicity. TCDD-treated c-src deficient mice show only modest degrees of hepatomegaly and triglycerides accumulation as compared to treated wild-type mice. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1241 / 1246

页数：6

共 6 条

[1]

BUTLER WM, 1961, J LIPID RES, V2, P95

[2] EVIDENCE FOR A 2ND PATHWAY IN THE ACTION MECHANISM OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) - SIGNIFICANCE OF AH-RECEPTOR MEDIATED ACTIVATION OF PROTEIN-KINASE UNDER CELL-FREE CONDITIONS [J].