Synthesis of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide derivatives as potential allosteric modulators of AMPA/kainate receptors

被引：47

作者：

Braghiroli, D

Puia, G

Cannazza, G

Tait, A

Parenti, C

Losi, G

Baraldi, M

机构：

[1] Univ G DAnnunzio, Dipartimento Sci Farmaco, I-66013 Chieti, Italy

[2] Univ Modena, Dipartimento Sci Farmaceut, I-41100 Modena, Italy

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2002年 / 45卷 / 12期

关键词：

D O I：

10.1021/jm025510d

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide derivatives were synthesized and evaluated for their activity as allosteric modulators of kainate-activated currents in primary cultures of cerebellar granule neurons. Substitution of different groups at the 3-position of the benzothiadiazine ring distinguished between positive and negative allosteric modulatory properties.

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页码：2355 / 2357

页数：3

相关论文

共 22 条

[1] Effect of the AMPA receptor modulator IDRA 21 on LTP in hippocampal slices [J].

Arai, A ;

Guidotti, A ;

Costa, E ;

Lynch, G .

NEUROREPORT, 1996, 7 (13) :2211-2215

[2]

BERTOLINO M, 1993, RECEPTOR CHANNEL, V1, P267

[3] A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].

BLISS, TVP ;

COLLINGRIDGE, GL .

NATURE, 1993, 361 (6407) :31-39

[4]

Cannazza G, 2001, CHIRALITY, V13, P94, DOI 10.1002/1520-636X(2001)13:2<94::AID-CHIR1004>3.0.CO

[5]

2-O

[6] Chiral resolution of the enantiomers of 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide using high-performance liquid chromatography on cellulose-based chiral stationary phases [J].

Cannazza, G ;

Braghiroli, D ;

Baraldi, M ;

Parenti, C .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2000, 23 (01) :117-125

[7]

CANNAZZA G, IN PRESS J PHARM BIO

[8]

Dingledine R, 1999, PHARMACOL REV, V51, P7

[9] SELECTIVE RELEASE OF GLUTAMATE FROM CEREBELLAR GRANULE CELLS DIFFERENTIATING IN CULTURE [J].

GALLO, V ;

CIOTTI, MT ;

COLETTI, A ;

ALOISI, F ;

LEVI, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (24) :7919-7923

[10] IMPROVED PATCH-CLAMP TECHNIQUES FOR HIGH-RESOLUTION CURRENT RECORDING FROM CELLS AND CELL-FREE MEMBRANE PATCHES [J].

HAMILL, OP ;

MARTY, A ;

NEHER, E ;

SAKMANN, B ;

SIGWORTH, FJ .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1981, 391 (02) :85-100