Compactness of human housekeeping genes: selection for economy or genomic design?

被引：129

作者：

Vinogradov, AE ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Cytol, St Petersburg 194064, Russia

来源：

TRENDS IN GENETICS | 2004年 / 20卷 / 05期

基金：

俄罗斯基础研究基金会;

关键词：

D O I：

10.1016/j.tig.2004.03.006

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The short length of human housekeeping genes, compared with tissue-specific genes, has been attributed to selection for economy in transcription and translation. In this article, I show that the non-transcribed intergenic spacer around housekeeping genes is also short, which suggests that short housekeeping genes are a result of local genome organization. Tissue-specific genes are longer than housekeeping genes because they have more functional domains, which is an indication of their more-complex protein architecture.

引用

页码：248 / 253

页数：6

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