Dimeric aminoglycosides: Design, synthesis and RNA binding

被引：52

作者：

Wang, H

Tor, Y

机构：

[1] Dept. of Chemistry and Biochemistry, University of California, San Diego

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(97)00339-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The design and synthesis of symmetrical and non-symmetrical dimeric aminoglycosides derived from kanamycin A, tobramycin, and neomycin B are described. The covalently-linked dimeric aminoglycosides show enhanced activity as ribozyme inhibitors when compared to their natural counterparts. (C) 1997 Elsevier Science Ltd.

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页码：1951 / 1956

页数：6

相关论文

共 15 条

[1] NEOMYCIN INHIBITION OF THE HAMMERHEAD RIBOZYME INVOLVES IONIC INTERACTIONS [J].

CLOUETDORVAL, B ;

STAGE, TK ;

UHLENBECK, OC .

BIOCHEMISTRY, 1995, 34 (35) :11186-11190

[2] KINETICS OF INTERMOLECULAR CLEAVAGE BY HAMMERHEAD RIBOZYMES [J].

FEDOR, MJ ;

UHLENBECK, OC .

BIOCHEMISTRY, 1992, 31 (48) :12042-12054

[3] Structure of the A site of Escherichia coli 16S ribosomal RNA complexed with an aminoglycoside antibiotic [J].

Fourmy, D ;

Recht, MI ;

Blanchard, SC ;

Puglisi, JD .

SCIENCE, 1996, 274 (5291) :1367-1371

[4] Direct observation of aminoglycoside-RNA interactions by surface plasmon resonance [J].

Hendrix, M ;

Priestley, ES ;

Joyce, GF ;

Wong, CH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (16) :3641-3648

[5] Saccharide-RNA recognition in an aminoglycoside antibiotic-RNA aptamer complex [J].

Jiang, LC ;

Suri, AK ;

Fiala, R ;

Patel, DJ .

CHEMISTRY & BIOLOGY, 1997, 4 (01) :35-50

[6] INHIBITION OF AN HIV-1 TAT-DERIVED PEPTIDE BINDING TO TAR RNA BY AMINOGLYCOSIDE ANTIBIOTICS [J].

MEI, HY ;

GALAN, AA ;

HALIM, NS ;

MACK, DP ;

MORELAND, DW ;

SANDERS, KB ;

TRUONG, HN ;

CZARNIK, AW .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (22) :2755-2760

[7] INTERACTION OF ANTIBIOTICS WITH FUNCTIONAL SITES IN 16S RIBOSOMAL-RNA [J].

MOAZED, D ;

NOLLER, HF .

NATURE, 1987, 327 (6121) :389-394

[8] INTERACTIONS OF A SMALL RNA WITH ANTIBIOTIC AND RNA LIGANDS OF THE 30S SUBUNIT [J].

PUROHIT, P ;

STERN, S .

NATURE, 1994, 370 (6491) :659-662

[9] SPLICE-SITE SELECTION AND DECODING - ARE THEY RELATED [J].

SCHROEDER, R ;

STREICHER, B ;

WANK, H .

SCIENCE, 1993, 260 (5113) :1443-1444

[10]

STAGE TK, 1995, RNA, V1, P95