Reversal of the inhibitory effect of Fondaparinux on Thrombin generation by rFVIIa, aCCP and PCC

被引：43

作者：

Desmurs-Clavel, H. ^{[2
]}

Huchon, C. ^{[1
]}

Chatard, B. ^{[1
]}

Negrier, C. ^{[1
,3
]}

Dargaud, Y. ^{[1
,3
]}

机构：

[1] Hop Edouard Herriot, Hemostase Lab, Lyon, France

[2] Hop Edouard Herriot, Serv Med Interne, Lyon, France

[3] Univ Lyon 1, IFR 62, EA 4174, F-69365 Lyon, France

来源：

THROMBOSIS RESEARCH | 2009年 / 123卷 / 05期

关键词：

Fondaparinux; Activated prothrombin complex concentrate; Recombinant factor VIIa; Prothrombin comlex concentrate; Thrombin generation test; HEPARIN; COMPLEX; PLASMA; HEMOPHILIA; ENOXAPARIN; CAPACITY;

D O I：

10.1016/j.thromres.2008.07.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adverse events associated with the administration of fondaparinux are mainly bleeding complications. Fondaparinux lacks specific antidotes and there is no routine laboratory assay for monitoring the efficacy of fondaparinux. Thrombin generation test measures the kinetic of thrombin formation over time which is a more complete characterisation of the individual coagulation capacity than classical clot based assays. In the present study the reversal effect of three procoagulant molecules was tested on the anticoagulant effect of fondaparinux. A complete correction of thrombin generating capacity was found with low doses of Feiba while rFVIIa was responsible for a partial correction of the coagulation capacity. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：796 / 798

页数：3

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