Effects of natural suppressor cells on production of Th1 and Th2 cytokines and proliferation of polarized T cells

被引：1

作者：

Bel'skaya, N. V. ^{[1
]}

Bel'skii, Yu. P. ^{[1
]}

Danilets, M. G. ^{[1
]}

Trofimova, E. S. ^{[1
]}

Sherstoboev, E. Yu. ^{[1
]}

Agafonov, V. I. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Siberian Div, Tomsk Res Ctr, Inst Pharmacol, Tomsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2006年 / 141卷 / 04期

关键词：

natural suppressor cells; interferon-gamma; interleukin-2; interleukin-4;

D O I：

10.1007/s10517-006-0194-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Natural suppressor cells from the bone marrow of intact animals and mice with Th1- and Th2-dependent immune response largely suppressed the production of Th1 (IFN-gamma, IL-2) and Th2 cytokines (IL-4). Antiproliferative activity of natural suppressor cells from intact and immunized animals was mediated by NO. Proliferation of Th1 cells was suppressed greater than that of Th2 cells. This selective effect of natural suppressor cells on the proliferation of target lymphocytes was due to higher stimulatory potential of Th1 cells (in comparison with Th2) towards natural suppressor cells.

引用

页码：440 / 443

页数：4

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