Chemotherapeutic drugs - more really is not better

被引：96

作者：

Fidler, IJ ^{[1
]}

Ellis, LM ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Canc Biol 173, Houston, TX 77030 USA

来源：

NATURE MEDICINE | 2000年 / 6卷 / 05期

关键词：

D O I：

10.1038/74969

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent insights into the molecular mechanisms that regulate the process of metastasis and the complex interactions between metastatic cells and host factors have provided a biological foundation for the design of more effective therapies.

引用

页码：500 / 502

页数：3

共 18 条

[1] Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model
Arap, W
Pasqualini, R
Ruoslahti, E
[J]. SCIENCE, 1998, 279 (5349) : 377 - 380
[2] ANGIOGENESIS INHIBITION - A REVIEW
AUERBACH, W
AUERBACH, R
[J]. PHARMACOLOGY & THERAPEUTICS, 1994, 63 (03) : 265 - 311
[3] BAKER CH, 2000, P AM ASSOC CANC RES, V41, P308
[4] Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal
Benjamin, LE
Keshet, E
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (16) : 8761 - 8766
[5] Browder T, 2000, CANCER RES, V60, P1878
[6] INTERFERON ALFA-2A THERAPY FOR LIFE-THREATENING HEMANGIOMAS OF INFANCY
EZEKOWITZ, RAB
MULLIKEN, JB
FOLKMAN, J
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (22) : 1456 - 1463
[7] FIDLER IJ, 1990, CANCER RES, V50, P6130
[8] MODULATION OF THE ORGAN MICROENVIRONMENT FOR TREATMENT OF CANCER METASTASIS
FIDLER, IJ
[J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1995, 87 (21) : 1588 - 1592
[9] METASTASIS RESULTS FROM PREEXISTING VARIANT CELLS WITHIN A MALIGNANT-TUMOR
FIDLER, IJ
KRIPKE, ML
[J]. SCIENCE, 1977, 197 (4306) : 893 - 895
[10] Angiogenic zip code
Folkman, J
[J]. NATURE BIOTECHNOLOGY, 1999, 17 (08) : 749 - 749

← 1 2 →