Diabetes and Its Effect on Bone and Fracture Healing

被引：444

作者：

Jiao, Hongli ^{[1
]}

Xiao, E. ^{[1
,2
]}

Graves, Dana T. ^{[1
,2
]}

机构：

[1] Univ Penn, Sch Dent Med, Dept Periodont, Philadelphia, PA 19104 USA

[2] Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China

来源：

CURRENT OSTEOPOROSIS REPORTS | 2015年 / 13卷 / 05期

关键词：

Diabetes; Inflammation; Advanced glycation end product (AGE); Oxidative stress; Insulin; Hyperglycemia; Osteoblast; Osteoclast; Fracture healing; GLYCATION END-PRODUCTS; LOCAL INSULIN DELIVERY; OXIDATIVE STRESS; HIGH GLUCOSE; NONENZYMATIC GLYCATION; TNF-ALPHA; OSTEOBLASTIC DIFFERENTIATION; OSTEOCLAST FORMATION; PARATHYROID-HORMONE; METABOLIC-CONTROL;

D O I：

10.1007/s11914-015-0286-8

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Diabetes mellitus is a metabolic disorder that increases fracture risk, interferes with bone formation, and impairs fracture healing. Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) both increase fracture risk and have several common features that affect the bone including hyperglycemia and increased advanced glycation end product (AGE) formation, reactive oxygen species (ROS) generation, and inflammation. These factors affect both osteoblasts and osteoclasts leading to increased osteoclasts and reduced numbers of osteoblasts and bone formation. In addition to fracture healing, T1DM and T2DM impair bone formation under conditions of perturbation such as bacteria-induced periodontal bone loss by increasing osteoblast apoptosis and reducing expression of factors that stimulate osteoblasts such as BMPs and growth factors.

引用

页码：327 / 335

页数：9

共 108 条

[1]

Influence of Comorbidities: Neuropathy, Vasculopathy, and Diabetes on Healing Response Quality [J].

Ackermann, Paul W. ;

Hart, David A. .

ADVANCES IN WOUND CARE, 2013, 2 (08) :410-421

[2]

Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis [J].

Ai-Aql, Z. S. ;

Alagl, A. S. ;

Graves, D. T. ;

Gerstenfeld, L. C. ;

Einhorn, T. A. .

JOURNAL OF DENTAL RESEARCH, 2008, 87 (02) :107-118

[3]

Chemokine expression is upregulated in chondrocytes in diabetic fracture healing [J].

Alblowi, Jazia ;

Tian, Chen ;

Siqueira, Michelle F. ;

Kayal, Rayyan A. ;

McKenzie, Erin ;

Behl, Yugal ;

Gerstenfeld, Louis ;

Einhorn, Thomas A. ;

Graves, Dana T. .

BONE, 2013, 53 (01) :294-300

[4]

High Levels of Tumor Necrosis Factor-α Contribute to Accelerated Loss of Cartilage in Diabetic Fracture Healing [J].

Alblowi, Jazia ;

Kayal, Rayyan A. ;

Siqueria, Michelle ;

McKenzie, Erin ;

Krothapalli, Nanarao ;

McLean, Jody ;

Conn, Jason ;

Nikolajczyk, Barbara ;

Einhorn, Thomas A. ;

Gerstenfeld, Louis ;

Graves, Dana T. .

AMERICAN JOURNAL OF PATHOLOGY, 2009, 175 (04) :1574-1585

[5]

Advanced glycation end products stimulate osteoblast apoptosis via the MAP kinase and cytosolic apoptotic pathways [J].

Alikhani, Mani ;

Alikhani, Zoubin ;

Boyd, Coy ;

MacLellan, Christine M. ;

Raptis, Markos ;

Liu, Rongkun ;

Pischon, Nicole ;

Trackman, Philip C. ;

Gerstenfeld, Louis ;

Graves, Dana T. .

BONE, 2007, 40 (02) :345-353

[6]

Basic Biology of Skeletal Aging: Role of Stress Response Pathways [J].

Almeida, Maria ;

OBrien, Charles A. .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2013, 68 (10) :1197-1208

[7]

Gene Expression Dynamics during Diabetic Periodontitis [J].

Andriankaja, O. M. ;

Galicia, J. ;

Dong, G. ;

Xiao, W. ;

Alawi, F. ;

Graves, D. T. .

JOURNAL OF DENTAL RESEARCH, 2012, 91 (12) :1160-1165

[8]

The multifaceted role of the vasculature in endochondral fracture repair [J].

Bahney, Chelsea S. ;

Hu, Diane P. ;

Miclau, Theodore, III ;

Marcucio, Ralph S. .

FRONTIERS IN ENDOCRINOLOGY, 2015, 6

[9]

Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-κB [J].

Bai, XC ;

Lu, D ;

Bai, J ;

Zheng, H ;

Ke, ZY ;

Li, XM ;

Luo, SQ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 314 (01) :197-207

[10]

FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation [J].

Bartell, Shoshana M. ;

Kim, Ha-Neui ;

Ambrogini, Elena ;

Han, Li ;

Iyer, Srividhya ;

Ucer, S. Serra ;

Rabinovitch, Peter ;

Jilka, Robert L. ;

Weinstein, Robert S. ;

Zhao, Haibo ;

O'Brien, Charles A. ;

Manolagas, Stavros C. ;

Almeida, Maria .

NATURE COMMUNICATIONS, 2014, 5

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