Cloning of novel splice variants of mouse mGluR1

被引：37

作者：

Zhu, H ^{[1
]}

Ryan, K ^{[1
]}

Chen, S ^{[1
]}

机构：

[1] Rutgers State Univ, Coll Pharm, Dept Biol Chem, Canc Res Lab, Piscataway, NJ 08855 USA

来源：

MOLECULAR BRAIN RESEARCH | 1999年 / 73卷 / 1-2期

关键词：

metabotropic glutamate receptor; soluble extracellular fragment of receptor; alternative slicing;

D O I：

10.1016/S0169-328X(99)00239-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Three splice variants of the mouse metabotropic glutamate receptor 1, mGluR1E55, mGluR1a and mGluR1b, have been isolated from mouse brain cDNA libraries. The sequences of mGluR1a and mGluR1b are similar to those from rat and human, mGluR1E55 is a novel splice variant. mGluR1E55 has two additional exons. One is 80-bp long at the 5' untranslational region. The other (E55) is 110-bp long at the cysteine-rich region after the ligand-binding domain and before the seven-transmembrane domain. Insertion of the E55 exon results in an inframe stop codon. The predicted protein product contains only the extracellular domain of the receptor and may be secreted. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：93 / 103

页数：11

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