Crystallographic structures of human alpha-thrombin complexed to peptide boronic acids lacking a positive charge at P1. Evidence of novel interactions

被引：17

作者：

Skordalakes, E

Tyrell, R

Elgendy, S

Goodwin, CA

Green, D

Dodson, G

Scully, MF

Freyssinet, JMH

Kakkar, VV

Deadman, JJ

机构：

[1] NATL INST MED RES, LONDON NW7 1AA, ENGLAND

[2] INST HEMATOL & IMMUNOL, F-67085 STRASBOURG, FRANCE

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1997年 / 119卷 / 41期

关键词：

D O I：

10.1021/ja9713338

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：9935 / 9936

页数：2

共 22 条

[1] THE CCP4 SUITE - PROGRAMS FOR PROTEIN CRYSTALLOGRAPHY [J].

BAILEY, S .

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 1994, 50 :760-763

[2]

BANNER DW, 1991, J BIOL CHEM, V266, P20085

[3]

BODE W, 1992, PROTEIN SCI, V1, P426

[4] BENZYLOXYCARBONYL-D-PHE-PRO-METHOXYPROPYLBOROGLYCINE - A NOVEL INHIBITOR OF THROMBIN WITH HIGH SELECTIVITY CONTAINING A NEUTRAL SIDE-CHAIN AT THE P1 POSITION [J].

CLAESON, G ;

PHILIPP, M ;

AGNER, E ;

SCULLY, MF ;

METTERNICH, R ;

KAKKAR, VV ;

DESOYZA, T ;

NIU, LH .

BIOCHEMICAL JOURNAL, 1993, 290 :309-312

[5] CHARACTERIZATION OF A CLASS OF PEPTIDE BORONATES WITH NEUTRAL P1 SIDE-CHAINS AS HIGHLY SELECTIVE INHIBITORS OF THROMBIN [J].

DEADMAN, JJ ;

ELGENDY, S ;

GOODWIN, CA ;

GREEN, D ;

BABAN, JA ;

PATEL, G ;

SKORDALAKES, E ;

CHINO, N ;

CLAESON, G ;

KAKKAR, VV ;

SCULLY, MF .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (09) :1511-1522

[6] S-1 heterocyclic thrombin inhibitors [J].

Dominguez, C ;

Carini, DJ ;

Weber, PC ;

Knabb, RM ;

Alexander, RS ;

Kettner, CA ;

Wexler, RR .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (01) :79-84

[7] FACILE ROUTES TO 1-HALO-1-ALKYL BORONIC ESTERS AS PRECURSORS FOR NOVEL THROMBIN INHIBITORS [J].

ELGENDY, S ;

CLAESON, G ;

KAKKAR, VV ;

GREEN, D ;

PATEL, G ;

GOODWIN, CA ;

BABAN, JA ;

SCULLY, MF ;

DEADMAN, J .

TETRAHEDRON, 1994, 50 (12) :3803-3812

[8] (N-acyl-N-alkyl)glycyl borolysine analogs: A new class of potent thrombin inhibitors [J].

Galemmo, RA ;

Fevig, JM ;

Carini, DJ ;

Cacciola, J ;

Wells, BL ;

Hillyer, GL ;

Buriak, J ;

Rossi, KA ;

Stouten, PFW ;

Alexander, RS ;

Hilmer, R ;

Bostrom, L ;

Abelman, MM ;

Lee, SL ;

Weber, PC ;

Kettner, CA ;

Knabb, RM ;

Wexler, RR .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (24) :2913-2918

[9] Functionality map analysis of the active site cleft of human thrombin [J].

Grootenhuis, PDJ ;

Karplus, M .

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 1996, 10 (01) :1-10

[10]

HUBER R, 1974, J MOL BIOL, V89, P73, DOI 10.1016/0022-2836(74)90163-6

← 1 2 3 →