Endosomes, lysosomes: their implication in gene transfer

被引：187

作者：

Wattiaux, R ^{[1
]}

Laurent, N ^{[1
]}

Wattiaux-De Coninck, S ^{[1
]}

Jadot, M ^{[1
]}

机构：

[1] Fac Univ Notre Dame Paix, Chim Physiol Lab, B-5000 Namur, Belgium

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2000年 / 41卷 / 02期

关键词：

endosomes; lysosomes; gene transfer;

D O I：

10.1016/S0169-409X(99)00066-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Plasmid DNA, naked or bound to a non-viral vector, is taken up by endocytosis. As a result, it has to travel through the intracellular endocytic pathway involving endosomes and lysosomes. However, some DNA molecules must escape these organelles to reach the nucleus where transcription takes place. In this paper, we consider different factors that could affect the trafficking of plasmid DNA and influence transfection efficiency. (C) 2000 Elsevier Science BN. All rights reserved.

引用

页码：201 / 208

页数：8

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