A mouse model with features of familial combined hyperlipidemia

被引：117

作者：

MasucciMagoulas, L

Goldberg, IJ

Bisgaier, CL

Serajuddin, H

Francone, OL

Breslow, JL

Tall, AR

机构：

[1] COLUMBIA UNIV,DEPT MED,NEW YORK,NY 10032

[2] WARNER LAMBERT PARKE DAVIS,PARKE DAVIS PHARMACEUT RES,DEPT VASC & CARDIAC DIS,ANN ARBOR,MI 48105

[3] PFIZER INC,DIV CENT RES,DEPT METAB DIS,GROTON,CT 06340

[4] ROCKEFELLER UNIV,BIOCHEM GENET & METAB LAB,NEW YORK,NY 10021

来源：

SCIENCE | 1997年 / 275卷 / 5298期

关键词：

D O I：

10.1126/science.275.5298.391

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Familial combined hyperlipidemia (FCHL) is a common inherited lipid disorder, affecting 1 to 2 percent of the population in Westernized societies. Individuals with FCHL have large quantities of very low density lipoprotein (VLDL) and low density lipoprotein (LDL) and develop premature coronary heart disease. A mouse model displaying some of the features of FCHL was created by crossing mice carrying the human apolipoprotein C-III (APOC3) transgene with mice deficient in the LDL receptor. A synergistic interaction between the apolipoprotein C-III and the LDL receptor defects produced large quantities of VLDL and LDL and enhanced the development of atherosclerosis. This mouse model may provide clues to the origin of human FCHL.

引用

页码：391 / 394

页数：4

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