Hyper-IgM syndromes: a model for studying the regulation of class switch recombination and somatic hypermutation generation

被引：35

作者：

Durandy, A ^{[1
]}

机构：

[1] Hop Necker Enfants Malad, INSERM, U429, Paris, France

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2002年 / 30卷

关键词：

activation-induced cytidine deaminase B-lymphocyte; maturation; CD40-CD40-ligand interaction; germinal centre;

D O I：

10.1042/bst0300815

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several genetic defects in class switch recombination, which lead to a hyper-IgM syndrome, have been described recently in humans. In addition to the well known role of CD40-ligand-CD40 interaction, these pathologies demonstrate definitively the requirement of CD40-mediated nuclear factor kappaB activation and the essential role of a recently described molecule, the activation-induced cytidine deaminase in an efficient humoral response, which includes class switch recombination and the production of high-affinity antibodies.

引用

页码：815 / 818

页数：4

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