A potential regulatory polymorphism upstream of hairy is not associated with bristle number variation in wild-caught drosophila

被引：29

作者：

Macdonald, SJ ^{[1
]}

Long, AD ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Ecol & Evolutionary Biol, Irvine, CA 92697 USA

来源：

GENETICS | 2004年 / 167卷 / 04期

关键词：

D O I：

10.1534/genetics.104.026732

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

To extend results from laboratory genetic mapping experiments to natural populations it is necessary to estimate the phenotypic effects attributable to laboratory-identified genetic factors in nature. We retested a polymorphism found to be strongly associated with an increase of 0.35 sternopleural bristles in laboratory strains in two large samples of wild-caught Drosophila melanogaster. Despite >90% power to detect effects as low as 0.27 bristles (<1% of the total variation in bristle number) we did not replicate the association in nature. Potential explanations for this result are explored.

引用

页码：2127 / 2131

页数：5

共 20 条

[1]

CHURCHILL GA, 1994, GENETICS, V138, P963

[2] The variant call format and VCFtools [J].

Danecek, Petr ;

Auton, Adam ;

Abecasis, Goncalo ;

Albers, Cornelis A. ;

Banks, Eric ;

DePristo, Mark A. ;

Handsaker, Robert E. ;

Lunter, Gerton ;

Marth, Gabor T. ;

Sherry, Stephen T. ;

McVean, Gilean ;

Durbin, Richard .

BIOINFORMATICS, 2011, 27 (15) :2156-2158

[3] Evidence that Egfr contributes to cryptic genetic variation for photoreceptor determination in natural populations of Drosophila melanogaster [J].

Dworkin, I ;

Palsson, A ;

Birdsall, K ;

Gibson, G .

CURRENT BIOLOGY, 2003, 13 (21) :1888-1893

[4]

Falconer D.S., 1996, Quantitative Genetics, V4th

[5] No evidence for an association between common nonsynonymous polymorphisms in Delta and bristle number variation in natural and laboratory populations of Drosophila melanogaster [J].

Genissel, A ;

Pastinen, T ;

Dowell, A ;

Mackay, TFC ;

Long, AD .

GENETICS, 2004, 166 (01) :291-306

[6]

Gurganus MC, 1998, GENETICS, V149, P1883

[7]

Gurganus MC, 1999, GENETICS, V152, P1585

[8] VARIATION FOR METRICAL CHARACTERS IN DROSOPHILA POPULATIONS .2. NATURAL SELECTION [J].

KEARSEY, MJ ;

BARNES, BW .

HEREDITY, 1970, 25 :11-&

[9] GENETIC UNIFORMITY IN 2 POPULATIONS OF DROSOPHILA-MELANOGASTER AS REVEALED BY FILTER HYBRIDIZATION OF 4-NUCLEOTIDE-RECOGNIZING RESTRICTION ENZYME DIGESTS [J].

KREITMAN, M ;

AGUADE, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (10) :3562-3566

[10] NATURALLY-OCCURRING VARIATION IN BRISTLE NUMBER AND DNA POLYMORPHISMS AT THE SCABROUS LOCUS OF DROSOPHILA-MELANOGASTER [J].

LAI, CG ;

LYMAN, RF ;

LONG, AD ;

LANGLEY, CH ;

MACKAY, TFC .

SCIENCE, 1994, 266 (5191) :1697-1702

← 1 2 →