The role of innate mediators in inflammatory response

被引：41

作者：

Liew, FY ^{[1
]}

McInnes, IB

机构：

[1] Univ Glasgow, Dept Immunol & Bacteriol, Glasgow G11 6NT, Lanark, Scotland

[2] Univ Glasgow, Ctr Rheumat Dis, Glasgow G11 6NT, Lanark, Scotland

来源：

MOLECULAR IMMUNOLOGY | 2002年 / 38卷 / 12-13期

关键词：

innate cytokines; IL-15; IL-18; rheumatoid arthritis;

D O I：

10.1016/S0161-5890(02)00014-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cytokines produced by innate immune response can profoundly influence the subsequent adaptive immunity. IL-15 and -18 are two of several mediators produced by macrophages that perform such a function. Here we present recent data mainly from our own laboratory illustrating the important role of IL-15 and -18 in the induction and perpetuation of chronic inflammation during experimental and clinical rheumatoid synovitis. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：887 / 890

页数：4

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