Enantioselective reduction of α,β-unsaturated acylsilanes by chiral lithium amides

被引：48

作者：

Takeda, K ^{[1
]}

Ohnishi, Y ^{[1
]}

Koizumi, T ^{[1
]}

机构：

[1] Toyama Med & Pharmaceut Univ, Fac Pharmaceut Sci, Toyama 9300194, Japan

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 02期

关键词：

D O I：

10.1021/ol990574c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of beta-substituted acryloylsilanes I with lithium amides II affords a-silyl allylic alcohols III in high enantiomeric excess (>99%) via formal hydride transfer from the chiral lithium amide.

引用

页码：237 / 239

页数：3

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