Influence of a proton pump inhibitor-based therapy on Helicobacter pylori strain selection

被引：5

作者：

Hazell, SL ^{[1
]}

Mitchell, HM ^{[1
]}

Hanna, G ^{[1
]}

Daskalopoulos, G ^{[1
]}

机构：

[1] INNER W ENDOSCOPY CTR,SYDNEY,NSW 2204,AUSTRALIA

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 1997年 / 16卷 / 07期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1007/BF01708237

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The influence of the proton pump inhibitor lansoprazole on strain diversity in Helicobacter pylori infected patients was investigated. Multiple isolates of Helicobacter pylori obtained pre-and post-therapy from gastric antral and body biopsies in 22 patients were compared using the random amplified polymorphic DNA-polymerase chain reaction (RAPD-PCR) for analysis. Post-therapy strains exhibiting novel RAPD-profiles were found in 5 of 22 patients (4 of 11 patients treated with lansoprazole alone and 1 of 11 patients treated with lansoprazole plus amoxicillin), Proton pump inhibition may affect the microecology of the stomach by influencing the colonisation patterns of specific strains.

引用

页码：530 / 532

页数：3

共 15 条

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