New 1,3,5-triazine based chiral stationary phase for the high-performance liquid chromatographic separation of enantiomers

被引：19

作者：

Iuliano, A ^{[1
]}

Pieroni, E ^{[1
]}

Salvadori, P ^{[1
]}

机构：

[1] UNIV PISA,DIPARTIMENTO CHIM & CHIM IND,CNR,CTR STUD MACROMOL STEREORDIN & OTTICAMENTE ATTIVE,I-56126 PISA,ITALY

来源：

JOURNAL OF CHROMATOGRAPHY A | 1997年 / 786卷 / 02期

关键词：

enantiomer separation; chiral stationary phases; LC; triazine-based stationary phases; amino acids;

D O I：

10.1016/S0021-9673(97)00578-5

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

2-Chloro-4-(S)-1-(1-naphthyl)ethylamino-6-L-Val-L-Val-L-valine isopropyl ester 1,3,5-triazine (I), a triazine derivative containing two different chiral moieties, was linked to 3-aminopropylsilanized silica, affording chiral stationary phase (CSP) TI, in order to verify its enantiodiscriminating capability and to make a comparison with similar triazine derivative CSPs containing only one kind of chiral moiety. CSP II was successfully employed for the HPLC separation of N-3,5-dinitrobenzoyl amino acid alkylesters and 2,2'-disubstituted-1,1'-binaphthyl compounds. Compound I was also used to prepare a different CSP by in situ derivatization of a prepacked 3-aminopropylsilanized silica column: the obtained CSP exhibited the same characteristics of the CSP prepared by conventional methods. (C) 1997 Elsevier Science B.V.

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收藏

页码：355 / 360

页数：6

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