Anterior thalamic lesions stop synaptic plasticity in retrosplenial cortex slices: expanding the pathology of diencephalic amnesia

被引:60
作者
Garden, Derek L. F. [1 ]
Massey, Peter V. [1 ]
Caruana, Douglas A. [1 ]
Johnson, Ben [1 ]
Warburton, E. Clea [1 ]
Aggleton, John P. [2 ]
Bashir, Zafar I. [1 ]
机构
[1] Univ Bristol, Dept Anat, MRC Ctr Synapt Plast, Bristol BS8 1TD, Avon, England
[2] Univ Cardiff, Dept Psychol, Cardiff CF10 3AT, Wales
基金
英国生物技术与生命科学研究理事会; 英国医学研究理事会;
关键词
diencephalic amnesia; long-term depression; diaschisis; retrosplenial cortex; anterior thalamus; Alzheimers disease; POSTERIOR CINGULATE CORTEX; MILD COGNITIVE IMPAIRMENT; ALCOHOLIC KORSAKOFFS-SYNDROME; LONG-TERM DEPRESSION; ALZHEIMERS-DISEASE; MATTER HYPOMETABOLISM; ANTEROGRADE AMNESIA; MEMORY; RAT; NUCLEI;
D O I
10.1093/brain/awp090
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Recent, convergent evidence places the anterior thalamic nuclei at the heart of diencephalic amnesia. However, the reasons for the severe memory loss in diencephalic amnesia remain unknown. A potential clue comes from the dense, reciprocal connections between the anterior thalamic nuclei and retrosplenial cortex, another region vital for memory. We now report a loss of synaptic plasticity [long-term depression (LTD)] in rat retrosplenial cortex slices months following an anterior thalamic lesion. The loss of LTD was lamina-specific, occurring only in superficial layers of the cortex and was associated with a decrease in GABA(A)-mediated inhibitory transmission. As retrosplenial cortex is itself vital for memory, this distal lesion effect will amplify the impact of anterior thalamic lesions. These findings not only provide novel insights into the functional pathology of diencephalic amnesia and have implications for the aetiology of the posterior cingulate hypoactivity in Alzheimers disease, but also show how distal changes in plasticity could contribute to diaschisis.
引用
收藏
页码:1847 / 1857
页数:11
相关论文
共 62 条
[1]   Understanding anterograde amnesia: Disconnections and hidden lesions [J].
Aggleton, John P. .
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY, 2008, 61 (10) :1441-1471
[2]  
Aggleton JP, 1999, BEHAV BRAIN SCI, V22, P425
[3]   The relationships between temporal lobe and diencephalic structures implicated in anterograde amnesia [J].
Aggleton, JP ;
Saunders, RC .
MEMORY, 1997, 5 (1-2) :49-71
[4]   The effects of selective lesions within the anterior thalamic nuclei on spatial memory in the rat [J].
Aggleton, JP ;
Hunt, PR ;
Nagle, S ;
Neave, N .
BEHAVIOURAL BRAIN RESEARCH, 1996, 81 (1-2) :189-198
[5]  
Bachevalier J, 1996, HIPPOCAMPUS, V6, P553, DOI 10.1002/(SICI)1098-1063(1996)6:5<553::AID-HIPO8>3.0.CO
[6]  
2-J
[7]   THALAMOCORTICAL DIASCHISIS - POSITRON EMISSION TOMOGRAPHY IN HUMANS [J].
BARON, JC ;
LEVASSEUR, M ;
MAZOYER, B ;
LEGAULTDEMARE, F ;
MAUGUIERE, F ;
PAPPATA, S ;
JEDYNAK, P ;
DEROME, P ;
CAMBIER, J ;
TRANDINH, S ;
CAMBON, H .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1992, 55 (10) :935-942
[8]   ALZHEIMERS-DISEASE AFFECTS LIMBIC NUCLEI OF THE THALAMUS [J].
BRAAK, H ;
BRAAK, E .
ACTA NEUROPATHOLOGICA, 1991, 81 (03) :261-268
[9]   NEUROPATHOLOGICAL STAGING OF ALZHEIMER-RELATED CHANGES [J].
BRAAK, H ;
BRAAK, E .
ACTA NEUROPATHOLOGICA, 1991, 82 (04) :239-259
[10]   Both anteromedial and anteroventral thalamic lesions impair radial-maze learning in rats [J].
Byatt, G ;
DalrympleAlford, JC .
BEHAVIORAL NEUROSCIENCE, 1996, 110 (06) :1335-1348