FOXP3 ensembles in T-cell regulation

被引：64

作者：

Li, Bin ^{[1
]}

Samanta, Arabinda ^{[1
]}

Song, Xiaomin ^{[1
]}

Furuuchi, Keiji ^{[1
]}

Iacono, Kathryn T. ^{[1
]}

Kennedy, Sarah ^{[1
]}

Katsumata, Makoto ^{[1
]}

Saouaf, Sandra J. ^{[1
]}

Greene, Mark I. ^{[1
]}

机构：

[1] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

IMMUNOLOGICAL REVIEWS | 2006年 / 212卷

关键词：

D O I：

10.1111/j.0105-2896.2006.00405.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Our recent studies have identified dynamic protein ensembles containing forkhead box protein 3 (FOXP3) that provide insight into the molecular complexity of suppressor T-cell activities, and it is our goal to determine how these ensembles regulate FOXP3's transcriptional activity in vivo. In this review, we summarize our current understanding of how FOXP3 expression is induced and how FOXP3 functions in vivo as a transcriptional regulator by assembling a multisubunit complex involved in histone modification as well as chromatin remodeling.

引用

页码：99 / 113

页数：15

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