Evaluation of the effect of caloric restriction on serum BDNF in overweight and obese subjects: preliminary evidences

被引:75
作者
Araya, A. Veronica [1 ]
Orellana, Ximena [2 ]
Espinoza, Jaime [3 ]
机构
[1] Univ Chile, Clin Hosp, Dept Internal Med, Endocrinol Sect, Santiago, Chile
[2] Univ Chile, Clin Hosp, Nutr Sect, Santiago, Chile
[3] Univ Chile, Clin Hosp, Lab Endocrinol & Biol Reprod, Santiago, Chile
关键词
Serum BDNF; Reduced-calorie diet; Obesity; Overweight;
D O I
10.1007/s12020-008-9090-x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Brain-derived neurotrophic factor (BDNF) has emerged as a new element related with insulin resistance and obesity. Objective To evaluate the effect of a 3-month reduced-calorie diet (RCD) on serum BDNF concentrations in overweight and obese subjects. Subjects Seventeen healthy overweight and obese subjects of both sexes (2448 years, BMI 34.6 +/- 1.1 kg/m(2)). Methods Anthropometry, oral glucose tolerance test (OGTT), lipid levels, and serum BDNF were measured at baseline and at the end of the third month. Reduced-calorie diet was defined as a 25% reduction in energy intake composed of: 55% carbohydrates, 20% proteins, and 25% fat (less than 10% saturated fat and over 10% nonsaturated fat). Refined sugar was not allowed. Results There was a significant decrease in BMI, waist circumference, body fat percentage, fasting glucose, post-OGTT glucose levels, area under the curve of glucose, and HOMA2-IR after 3 months of RCD. Serum BDNF showed a significant increase (3.97 +/- 0.87 to 6.75 +/- ! 1.62 ng/ml, P = 0.02). Final serum BDNF correlated negatively with weight (r = -0.51, P = 0.03), and basal post-OGTT insulin correlated positively with final serum BDNF (r = 0.48, P = 0.04). Conclusions Serum BDNF increases in insulin-resistant overweight and obese subjects after three months on a RCD. This observation could indicate that BDNF may be modulated in humans through diet composition.
引用
收藏
页码:300 / 304
页数:5
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