Gut microbial metabolism defines host metabolism: an emerging perspective in obesity and allergic inflammation

被引：109

作者：

Kumari, M.

Kozyrskyj, A. L. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Alberta, Fac Med & Dent, Dept Pediat, Edmonton, AB, Canada

[2] Univ Alberta, Fac Med & Dent, Dept Obstet & Gynecol, Edmonton, AB, Canada

[3] Univ Alberta, Sch Publ Hlth, Edmonton, AB, Canada

[4] Univ Alberta, Dept Pediat, # 3-527,Edmonton Clinic Hlth Acad ECHA Bldg 1, Edmonton, AB T6G IC9, Canada

来源：

OBESITY REVIEWS | 2017年 / 18卷 / 01期

关键词：

Gut; microbiota; overweight; short chain fatty acids; CHAIN FATTY-ACIDS; DIETARY FIBER; MEGASPHAERA-ELSDENII; APPETITE REGULATION; BUTYRATE PRODUCTION; LARGE-INTESTINE; BATCH CULTURE; HUMAN COLON; HUMAN FECES; LIFE-STYLE;

D O I：

10.1111/obr.12484

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The presence of >100 trillion microorganisms (collectively called gut microbiota) in our large intestine is essential for the maintenance of health. The gut microbiota starts to develop before birth and matures within first three years of life. The Western diet and lifestyle have been implicated in causing an imbalance of gut microbial communities and their metabolites that consequence in disease states, such as obesity and asthma. With more than 13% of the world population currently living with obesity and one out of 10 children diagnosed with asthma, we explore here the recent developments in the biosynthesis and mode of action of the key metabolites in relation to these two chronic inflammatory conditions.

引用

页码：18 / 31

页数：14

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