The effect of linomide on the migration and the proliferation of capillary endothelial cells elicited by vascular endothelial growth factor

被引：20

作者：

Parenti, A

Donnini, S

Morbidelli, L

Granger, HJ

Ziche, M

机构：

[1] UNIV FLORENCE, DEPT PHARMACOL, I-50134 FLORENCE, ITALY

[2] TEXAS A&M UNIV, HLTH SCI CTR, MICROCIRCULAT RES INST, COLLEGE STN, TX USA

[3] TEXAS A&M UNIV, HLTH SCI CTR, DEPT MED PHYSIOL, COLLEGE STN, TX USA

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1996年 / 119卷 / 04期

关键词：

vascular endothelial growth factor; linomide; capillary endothelial cells; migration; proliferation; antiangiogenesis;

D O I：

10.1111/j.1476-5381.1996.tb15718.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In order to assess the mechanism of action of the quinoline-3-carboxyamide linomide as an antiangiogenic drug, the effect of linomide was studied in vitro on postcapillary endothelial cells exposed to vascular endothelial growth factor (VEGF). Linomide did not block the spontaneous replication of endothelial cells, but significantly suppressed endothelial cell growth and migration elicited by VEGF. It is concluded that linomide appears to be an effective tool to inhibit VEGF-dependent angiogenesis.

引用

页码：619 / 621

页数：3

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