Neuregulin 1 improves complex 2-mediated mitochondrial respiration in skeletal muscle of healthy and diabetic mice

被引：21

作者：

Ennequin, Gael ^{[1
,4
,5
]}

Capel, Frederic ^{[2
]}

Caillaud, Kevin ^{[1
]}

Chavanelle, Vivien ^{[1
]}

Etienne, Monique ^{[1
]}

Teixeira, Allison ^{[1
]}

Li, Xinyan ^{[3
]}

Boisseau, Nathalie ^{[1
]}

Sirvent, Pascal ^{[1
]}

机构：

[1] Univ Clermont Auvergne, Lab Adaptat Metabol Exercice Condit Physiol & Pat, F-63000 Clermont Ferrand, France

[2] Univ Clermont Auvergne, Lab Adaptat Metabol Exercice Condit Physiol & Pat, F-63000 Clermont Ferrand, France

[3] Univ Auvergne, INRA, Lab Nutr Humaine, Nutr Humaine UMR1019,CRNH, F-63009 Clermont Ferrand 1, France

[4] Zensun Sci & Tech Ltd, Shanghai, Peoples R China

[5] PEPITE EA4267, F-25000 Besancon, France

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

关键词：

INDUCED INSULIN-RESISTANCE; INCREASED EXPRESSION; OXIDATIVE CAPACITY; GLUCOSE-TOLERANCE; RAT MODEL; DYSFUNCTION; GROWTH; STRESS; DIFFERENTIATION; OVEREXPRESSION;

D O I：

10.1038/s41598-017-02029-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

It has been reported that neuregulin1 (NRG1) improves glucose tolerance in healthy and diabetic rodents. In vitro studies also suggest that NRG1 regulates myocyte oxidative capacity. To confirm this observation in vivo, we evaluated the effect on mitochondrial function of an 8-week treatment with NRG1 in db/db diabetic mice and C57BL/6JRJ healthy controls. NRG1 treatment improved complex 2-mediated mitochondrial respiration in the gastrocnemius of both control and diabetic mice and increased mitochondrial complex 2 subunit content by 2-fold. This effect was not associated with an increase in mitochondrial biogenesis markers. Enhanced ERBB4 phosphorylation could mediate NRG1 effects on mitochondrial function through signalling pathways, independently of ERK1/2, AKT or AMPK.

引用

页数：9

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