Substantially reduced expression of PIAS1 is associated with colon cancer development

被引：39

作者：

Coppola, Domenico ^{[3
]}

Parikh, Vevek ^{[1
]}

Boulware, David ^{[3
]}

Blanck, George ^{[1
,2
]}

机构：

[1] Univ S Florida, Coll Med, Dept Mol Med, Tampa, FL 33612 USA

[2] Univ S Florida, H Lee Moffitt Canc Ctr & Res Inst, Program Immunol, Tampa, FL 33612 USA

[3] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Anat Pathol, Tampa, FL 33612 USA

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2009年 / 135卷 / 09期

关键词：

Interferon-gamma; Colon cancer; PIAS1; IRF-1; STAT1; alpha; Adenoma; Tissue microarray; REGULATORY FACTOR-I; INTERFERON-GAMMA; SIGNALING PATHWAY; INDUCTION; APOPTOSIS; CELLS; TRANSCRIPTION; ACTIVATION;

D O I：

10.1007/s00432-009-0570-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Protein inhibitors of activated STATs (PIAS) regulate the interferon-gamma (IFN-gamma) signaling pathway, which has numerous effects on tumor development and tumor cell biology. PIAS's also regulate STAT family members not directly involved in IFN-gamma signaling. This project was designed to assess PIAS1 expression in colon cancer. To determine whether PIAS1, one of the PIAS family members, or IFN-gamma signaling pathway components could be used to stratify colon tumors, we stained tissue microarrays for PIAS1, interferon regulatory factor-1 (IRF-1) and STAT1 alpha. PIAS1 staining of the colon cancer tissue microarrays indicated a strong correlation of normal colon cells, and adenomas, with high expression of both PIAS1 and IRF-1. The PIAS1 results in particular may represent a basis for new approaches for efficiently distinguishing adenomas from colon cancer.

引用

页码：1287 / 1291

页数：5

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