Toll-like receptors as potential therapeutic targets for multiple diseases

被引：185

作者：

Zuany-Amorim, C ^{[1
]}

Hastewell, J ^{[1
]}

Walker, C ^{[1
]}

机构：

[1] Novartis Pharmaceut Ltd, Novartis Horsham Res Ctr, Horsham RH12 5AB, W Sussex, England

来源：

NATURE REVIEWS DRUG DISCOVERY | 2002年 / 1卷 / 10期

关键词：

D O I：

10.1038/nrd914

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The family of Toll-like receptors (TLRs) is receiving considerable attention as potential regulators and controllers of the immune response through their ability to recognize pathogen-associated molecular patterns. The discovery that endogenous ligands, as well as microbial components, are recognized by TLRs, and that small-molecular-mass synthetic compounds activate TLRs, raised interest in these receptors as potential targets for the development of new therapies for multiple diseases. In this review, we discuss the current and future use of TLR agonists or antagonists in chronic inflammatory diseases and highlight potential problems that are associated with such approaches.

引用

页码：797 / 807

页数：11

共 115 条

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