Muscarinic receptor antagonism causes a functional alteration in nucleus accumbens μ-opiate-mediated feeding behavior

被引：32

作者：

Perry, Michelle L. ^{[1
]}

Baldo, Brian A. ^{[1
]}

Andrzejewski, Matthew E. ^{[2
]}

Kelley, Ann E. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Psychiat, Madison, WI 53719 USA

[2] Univ Wisconsin, Waisman Ctr 225, Madison, WI 53705 USA

来源：

BEHAVIOURAL BRAIN RESEARCH | 2009年 / 197卷 / 01期

关键词：

Accumbens; Muscarinic; Opioid; Feeding; Scopolamine; Eating; Acetylcholine; GENE-EXPRESSION; FOOD MOTIVATION; ACETYLCHOLINE; STRIATUM; SHELL; RATS; STIMULATION; MODULATION; RELEASE; REWARD;

D O I：

10.1016/j.bbr.2008.08.002

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Intra-nucleus accumbens (Acb) infusion of cholinergic muscarinic antagonist, scopolamine (10 mu g/0.5 mu l), markedly reduced fat intake elicited by intra-Acb treatment of the mu-opioid receptor agonist, DAMGO, with 30 min and 4 h pretreatment intervals. Intra-Acb scopolamine infusions also reduced food intake in food-deprived rats, but not water intake in water-deprived rats. Hence, Acb muscarinic manipulations exhibit some specificity for feeding, perhaps via interactions with the striatal opioid system. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：225 / 229

页数：5

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