Community Case Clusters of Middle East Respiratory Syndrome Coronavirus in Hafr Al-Batin, Kingdom of Saudi Arabia: A Descriptive Genomic study

被引:65
作者
Memish, Ziad A. [1 ,2 ]
Cotten, Matthew [3 ]
Watson, Simon J. [3 ]
Kellam, Paul [3 ,4 ,5 ]
Zumla, Alimuddin [4 ,5 ]
Alhakeem, Rafat F. [1 ]
Assiri, Abdullah [1 ]
Al Rabeeah, Abdullah A. [1 ]
Al-Tawfiq, Jaffar A. [6 ,7 ]
机构
[1] Minist Hlth, GCMGM, Riyadh, Saudi Arabia
[2] Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia
[3] Wellcome Trust Sanger Inst, Hinxton, England
[4] UCL, Div Infect & Immun, London, England
[5] UCL Hosp NHS Fdn Trust, London, England
[6] Saudi Aramco Med Serv Org, Dhahran, Saudi Arabia
[7] Indiana Univ, Sch Med, Indianapolis, IN USA
关键词
Middle East; Community; Clusters; MERS-CoV; Genome; Phylogeny; Coronavirus; Virus transmission; CLINICAL-FEATURES; DROMEDARY CAMELS; FAMILY CLUSTER; INFECTIONS;
D O I
10.1016/j.ijid.2014.03.1372
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
The Middle East respiratory syndrome coronavirus (MERS-CoV) was first described in September 2012 and to date 86 deaths from a total of 206 cases of MERS-CoV infection have been reported to the WHO. Camels have been implicated as the reservoir of MERS-CoV, but the exact source and mode of transmission for most patients remain unknown. During a 3 month period, June to August 2013, there were 12 positive MERS-CoV cases reported from the Hafr Al-Batin region district in the north east region of the Kingdom of Saudi Arabia. In addition to the different regional camel festivals in neighboring countries, Hafr Al-Batin has the biggest camel market in the entire Kingdom and hosts an annual camel festival. Thus, we conducted a detailed epidemiological, clinical and genomic study to ascertain common exposure and transmission patterns of all cases of MERS-CoV reported from Hafr Al-Batin. Analysis of previously reported genetic data indicated that at least two of the infected contacts could not have been directly infected from the index patient and alternate source should be considered. While camels appear as the likely source, other sources have not been ruled out. More detailed case control studies with detailed case histories, epidemiological information and genomic analysis are being conducted to delineate the missing pieces in the transmission dynamics of MERS-CoV outbreak. (C) 2014 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-SA license
引用
收藏
页码:63 / 68
页数:6
相关论文
共 34 条
  • [1] Al-Tawfiq JA, 2013, SAUDI MED J, V34, P991
  • [2] AlBarrak AM, 2012, SAUDI MED J, V33, P1265
  • [3] [Anonymous], EURO SURVEILL
  • [4] [Anonymous], INT SURV REC HUM INF
  • [6] Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study
    Assiri, Abdullah
    Al-Tawfiq, Jaffar A.
    Al-Rabeeah, Abdullah A.
    Al-Rabiah, Fahad A.
    Al-Hajjar, Sami
    Al-Barrak, Ali
    Flemban, Hesham
    Al-Nassir, Wafa N.
    Balkhy, Hanan H.
    Al-Hakeem, Rafat F.
    Makhdoom, Hatem Q.
    Zumla, Alimuddin I.
    Memish, Ziad A.
    [J]. LANCET INFECTIOUS DISEASES, 2013, 13 (09) : 752 - 761
  • [7] Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus
    Assiri, Abdullah
    McGeer, Allison
    Perl, Trish M.
    Price, Connie S.
    Al Rabeeah, Abdullah A.
    Cummings, Derek A. T.
    Alabdullatif, Zaki N.
    Assad, Maher
    Almulhim, Abdulmohsen
    Makhdoom, Hatem
    Madani, Hossam
    Alhakeem, Rafat
    Al-Tawfiq, Jaffar A.
    Cotten, Matthew
    Watson, Simon J.
    Kellam, Paul
    Zumla, Alimuddin I.
    Memish, Ziad A.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (05) : 407 - 416
  • [8] Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk
    Breban, Romulus
    Riou, Julien
    Fontanet, Arnaud
    [J]. LANCET, 2013, 382 (9893) : 694 - 699
  • [9] CAUCHEMEZ S, 2013, LANCET INFECT DIS
  • [10] Chu DanielK W., 2014, Emerging Infectious Diseases, V20