Zanhasaponins A and B, antiphospholipase A(2) saponins from an antiinflammatory extract of Zanha africana root bark

被引：27

作者：

Cuellar, MJ

Giner, RM

Recio, MC

Just, MJ

Manez, S

Cerda, M

Hostettmann, K

Rios, JL

机构：

[1] UNIV VALENCIA,FAC FARM,DEPT FARMACOL,E-46100 BURJASSOT,VALENCIA,SPAIN

[2] UNIV VALENCIA,FAC MED,DEPT PATOL,VALENCIA,SPAIN

[3] UNIV LAUSANNE,ECOLE PHARM,INST PHARMACOGNOSIE & PHYTOCHIM,CH-1015 LAUSANNE,SWITZERLAND

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 11期

关键词：

D O I：

10.1021/np970221r

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A MeOH extract from Z. africana was examined for topical antiinflammatory activity and proved to be active against arachidonic acid (AA) acute edema, 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced chronic inflammation, and oxazolone delayed-type hypersensitivity in mice. The extract also showed significant inhibitory activity of Naja naja phospholipase A(2) when a polarographic method was used. Two oleanane-type triterpene saponins, zanhasaponins A (1) and B (2), and the cyclitol pinitol (rf), isolated from the extract, were active as inhibitors of PLA(2). A further saponin, zanhasaponin C (3) was inactive in this assay.

引用

页码：1158 / 1160

页数：3

共 11 条

[1] Three new oleanane saponins from Zanha africana [J].

Cuellar, MJ ;

Giner, RM ;

Recio, MD ;

Just, MJ ;

Manez, S ;

Rios, JL ;

Bilia, AR ;

Msonthi, J ;

Hostettmann, K .

JOURNAL OF NATURAL PRODUCTS, 1997, 60 (02) :191-194

[2] Two fungal lanostane derivatives as phospholipase A(2) inhibitors [J].

Cuellar, MJ ;

Giner, RM ;

Recio, MC ;

Just, MJ ;

Manez, S ;

Rios, JL .

JOURNAL OF NATURAL PRODUCTS, 1996, 59 (10) :977-979

[3]

DIMBI MZ, 1987, B SOC CHIM BELG, V96, P207

[4]

DIMBI MZ, 1984, B SOC CHIM BELG, V93, P323

[5]

KAPUNDU M, 1992, B SOC CHIM BELG, V101, P283

[6] REGULATION OF EXTRACELLULAR PHOSPHOLIPASE-A2 ACTIVITY - IMPLICATIONS FOR INFLAMMATORY DISEASES [J].

MUKHERJEE, AB ;

CORDELLAMIELE, E ;

MIELE, L .

DNA AND CELL BIOLOGY, 1992, 11 (03) :233-243

[7] Screening of tropical medicinal plants for antiinflammatory activity [J].

Recio, MC ;

Giner, RM ;

Manez, S ;

Rios, JL ;

Marston, A ;

Hostettmann, K .

PHYTOTHERAPY RESEARCH, 1995, 9 (08) :571-574

[8] INTERFACIAL CATALYSIS - THE MECHANISM OF PHOSPHOLIPASE-A2 [J].

SCOTT, DL ;

WHITE, SP ;

OTWINOWSKI, Z ;

YUAN, W ;

GELB, MH ;

SIGLER, PB .

SCIENCE, 1990, 250 (4987) :1541-1546

[9] MOUSE SKIN INFLAMMATION INDUCED BY MULTIPLE TOPICAL APPLICATIONS OF 12-O-TETRADECANOYLPHORBOL-13-ACETATE [J].

STANLEY, PL ;

STEINER, S ;

HAVENS, M ;

TRAMPOSCH, KM .

SKIN PHARMACOLOGY, 1991, 4 (04) :262-271

[10] ASSAY-METHOD FOR MYELOPEROXIDASE IN HUMAN POLYMORPHONUCLEAR LEUKOCYTES [J].

SUZUKI, K ;

OTA, H ;

SASAGAWA, S ;

SAKATANI, T ;

FUJIKURA, T .

ANALYTICAL BIOCHEMISTRY, 1983, 132 (02) :345-352

← 1 2 →