ER stress-induced cell death mechanisms

被引:1635
作者
Sano, Renata [1 ]
Reed, John C. [1 ]
机构
[1] Sanford Burnham Med Res Inst, La Jolla, CA 92037 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2013年 / 1833卷 / 12期
关键词
ER Stress; Cell death mechanisms; Diseases; ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; THIOREDOXIN-INTERACTING PROTEIN; BAX INHIBITOR-1; AUTOPHAGOSOME FORMATION; INDUCED APOPTOSIS; MITOCHONDRIAL APOPTOSIS; ALZHEIMERS-DISEASE; GLUCOSE-METABOLISM; NLRP3; INFLAMMASOME;
D O I
10.1016/j.bbamcr.2013.06.028
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The endoplasmic-reticulum (ER) stress response constitutes a cellular process that is triggered by a variety of conditions that disturb folding of proteins in the ER. Eukaryotic cells have developed an evolutionarily conserved adaptive mechanism, the unfolded protein response (1)PR), which aims to clear unfolded proteins and restore ER homeostasis. In cases where ER stress cannot be reversed, cellular functions deteriorate, often leading to cell death. Accumulating evidence implicates ER stress-induced cellular dysfunction and cell death as major contributors to many diseases, making modulators of ER stress pathways potentially attractive targets for therapeutics discovery. Here, we summarize recent advances in understanding the diversity of molecular mechanisms that govern ER stress signaling in health and disease. This article is part of a Special Section entitled: Cell Death Pathways. Guest Editors: Frank Madeo and Slaven Stekovic. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:3460 / 3470
页数:11
相关论文
共 116 条
  • [1] Translation Attenuation through elF2α Phosphorylation Prevents Oxidative Stress and Maintains the Differentiated State in β Cells
    Back, Sung Hoon
    Scheuner, Donalyn
    Han, Jaeseok
    Song, Benbo
    Ribick, Mark
    Wang, Junying
    Gildersleeve, Robert D.
    Pennathur, Subramaniam
    Kaufman, Randal J.
    [J]. CELL METABOLISM, 2009, 10 (01) : 13 - 26
  • [2] Transmembrane bZIP transcription factors in ER stress signaling and the unfolded protein response
    Bailey, Daniel
    O'Hare, Peter
    [J]. ANTIOXIDANTS & REDOX SIGNALING, 2007, 9 (12) : 2305 - 2321
  • [3] Hepatic Bax Inhibitor-1 Inhibits IRE1α and Protects from Obesity-associated Insulin Resistance and Glucose Intolerance
    Bailly-Maitre, Beatrice
    Belgardt, Bengt F.
    Jordan, Sabine D.
    Coornaert, Beatrice
    von Freyend, Miriam John
    Kleinridders, Andre
    Mauer, Jan
    Cuddy, Michael
    Kress, Christina L.
    Willmes, Diana
    Essig, Manuela
    Hampel, Brigitte
    Protzer, Ulrike
    Reed, John C.
    Bruening, Jens C.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (09) : 6198 - 6207
  • [4] A CHOP-regulated microRNA controls rhodopsin expression
    Behrman, Shannon
    Acosta-Alvear, Diego
    Walter, Peter
    [J]. JOURNAL OF CELL BIOLOGY, 2011, 192 (06) : 919 - 927
  • [5] Regulation of microRNA expression in the heart by the ATF6 branch of the ER stress response
    Belmont, Peter J.
    Chen, Wenqiong J.
    Thuerauf, Donna J.
    Glembotski, Christopher C.
    [J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2012, 52 (05) : 1176 - 1182
  • [6] Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response
    Bernales, Sebastian
    McDonald, Kent L.
    Walter, Peter
    [J]. PLOS BIOLOGY, 2006, 4 (12) : 2311 - 2324
  • [7] Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol
    Breckenridge, DG
    Stojanovic, M
    Marcellus, RC
    Shore, GC
    [J]. JOURNAL OF CELL BIOLOGY, 2003, 160 (07) : 1115 - 1127
  • [8] Bcl-2 associated athanogene 5 (Bag5) is overexpressed in prostate cancer and inhibits ER-stress induced apoptosis
    Bruchmann, Anja
    Roller, Corinna
    Walther, Tamara Vanessa
    Schaefer, Georg
    Lehmusvaara, Sara
    Visakorpi, Tapio
    Klocker, Helmut
    Cato, Andrew C. B.
    Maddalo, Danilo
    [J]. BMC CANCER, 2013, 13
  • [9] The C Terminus of Bax Inhibitor-1 Forms a Ca2+-permeable Channel Pore
    Bultynck, Geert
    Kiviluoto, Santeri
    Henke, Nadine
    Ivanova, Hristina
    Schneider, Lars
    Rybalchenko, Volodymyr
    Luyten, Tomas
    Nuyts, Koen
    De Borggraeve, Wim
    Bezprozvanny, Ilya
    Parys, Jan B.
    De Smedt, Humbert
    Missiaen, Ludwig
    Methner, Axel
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (04) : 2544 - 2557
  • [10] MicroRNA-30c-2*limits expression of proadaptive factor XBP1 in the unfolded protein response
    Byrd, Andrew E.
    Aragon, Ileana V.
    Brewer, Joseph W.
    [J]. JOURNAL OF CELL BIOLOGY, 2012, 196 (06) : 689 - 698