The frail elderly: role of dendritic cells in the susceptibility of infection

被引:80
作者
Uyemura, K
Castle, SC
Makinodan, T
机构
[1] Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA 90073 USA
[2] Vet Adm Greater Los Angeles Healthcare Syst, Ctr Geriatr Res Educ & Clin, Los Angeles, CA USA
关键词
aging; dendritic cells; frail elderly; cytokines;
D O I
10.1016/S0047-6374(02)00033-7
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The decline in immunity in the elderly has largely been attributed to impairment of T cell mechanisms. This seems reasonable since the thymus involutes with age, so that the number of naive cells to respond to new foreign antigens also declines. However, little is known about how aging affects antigen-presenting cells (APC) that are responsible for the initiation and outcome of effector T cell immune responses. This review focuses on the age-related alterations of a key APC, the dendritic cell (DC). Recent findings suggest that interleukin-10, a key cytokine that can suppress cell mediated immunity and maturation of DC subsets, is elevated in the very healthy elderly. However, production of IL-12, required for the initiation of T cell immune responses, declines in frail elderly along with DC antigen presenting function. These findings suggest that shifts in IL-10 and IL-12 may not only directly influence immune response but may also alter the balance and maturation of DC subsets. Finally, study of immunologic differences between the very healthy and frail elderly may reveal important changes in DC function and regulation influenced by age and/or environment (disease, nutrition, medications, etc.). (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:955 / 962
页数:8
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