Total synthesis of (-)-minquartynoic acid: An anti-cancer, anti-HIV natural product

被引：48

作者：

Gung, BW ^{[1
]}

Dickson, H ^{[1
]}

机构：

[1] Miami Univ, Dept Chem & Biochem, Oxford, OH 45056 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 15期

关键词：

D O I：

10.1021/ol026145n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHIC] The tetraacetylenic compound, (S)-minquartynoic acid (1), is synthesized in seven linear steps and 17% overall yield from commercially available azelaic acid monomethyl ester. The key step is a one-pot three-component Cadiot-Chodkiewiez reaction to construct the tetrayne unit without using either a diyne or a triyne intermediate.

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页码：2517 / 2519

页数：3

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