Carboxyl group (-CO2H) functionalized ferrimagnetic iron oxide nanoparticles for potential bio-applications

被引：336

作者：

Yu, S ^{[1
]}

Chow, GM

机构：

[1] Singapore Massachusetts Inst Technol Alliance, Singapore 117576, Singapore

[2] Natl Univ Singapore, Dept Mat Sci, Singapore 119260, Singapore

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2004年 / 14卷 / 18期

关键词：

D O I：

10.1039/b404964k

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A new approach to prepare surface-functionalized magnetic nanoparticles by synthesis of poly( methacrylic acid) (PMAA) coated maghemite nanoparticles in aqueous solution is reported. Maghemite (gamma-Fe2O3) nanoparticles with an average diameter of 8 +/- 2 nm were fabricated and subsequently coated with PMAA by emulsion polymerization. The FTIR study and thermal analysis confirmed the chemical adsorption of methacrylic acid on the maghemite nanoparticle surface, and suggested a symmetrical carboxylate bonding. The free carboxyl group of PMAA, which was verified by FTIR spectroscopy and zeta potential measurement, provided the site for immobilization of foreign molecules. The PMAA coated maghemite nanoparticles were demonstrated as potential magnetically targeted drug carriers by adsorbing an anti-cancer drug ( carboplatin) via the ion - dipole interaction between CO2- of PMAA and carboplatin.

引用

页码：2781 / 2786

页数：6

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