The role of cytotoxic necrotizing factor-1 in colonization and tissue injury in a murine model of urinary tract infection

被引：18

作者：

Johnson, DE

Drachenberg, C

Lockatell, CV

Island, MD

Warren, JW

Donnenberg, MS

机构：

[1] Dept Vet Affairs, Res Serv 151, Baltimore, MD 21201 USA

[2] Univ Maryland, Sch Med, Dept Pathol, Baltimore, MD 21201 USA

[3] Univ Maryland, Sch Med, Dept Med, Div Infect Dis, Baltimore, MD 21201 USA

来源：

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 2000年 / 28卷 / 01期

关键词：

urinary tract infection; pathogenesis; cytotoxic necrotizing factor; Escherichia coli;

D O I：

10.1111/j.1574-695X.2000.tb01454.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytotoxic necrotizing factor-1 (CNF1) is commonly found in Escherichia coli isolates from patients with urinary tract infection (UTI). To determine whether CNF1 is an important UTI virulence factor we compared the ability of a clinical E. coli UTI isolate and a CNF1-negative mutant of that isolate to colonize and induce histological changes in the urinary tract in a murine model of ascending UTI. We found no evidence that the mutant strain was attenuated. (C) 2000 Published by Elsevier Science B.V. All rights reserved.

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页码：37 / 41

页数：5

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