Rb, whi it's not just for metazoans anymore

被引：37

作者：

Cooper, K. ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Sch Osteopath Med, Dept Mol Biol, Stratford, NJ 08084 USA

来源：

ONCOGENE | 2006年 / 25卷 / 38期

关键词：

cyclin; cyclin dependent kinases; retinoblastoma; heterodimeric transcription factors; cell cycle; G1; progression;

D O I：

10.1038/sj.onc.1209630

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The E2F family of heterodimeric transcription factors controls the expression of genes required in G1 for cell cycle progression. The retinoblastoma ( Rb) family of pocket proteins which, upon binding to E2F, inhibit this complex from initiating transcription. Upon mitogen stimulation, this repression is relieved by hyperphosphorylation of Rb by the cyclin D Cdk4/6 complex. Initiation of the cell cycle in yeast is similar. The heterodimeric transcription factor SBF controls most G1-specific transcription. Its activation is dependent upon the removal of Whi5; a functional homolog of Rb. Similar to Rb, disassociation of Whi5 from SBF is controlled by G1 cyclin/Cdk-dependent phosphorylation. Although Rb and Whi5 play similar roles in regulating G1 gene expression, they exhibit no sequence homology. This review will discuss the difference and similarities between how these proteins play similar roles in controlling G1 progression.

引用

页码：5228 / 5232

页数：5

共 55 条

[1] MECHANISMS THAT HELP THE YEAST-CELL CYCLE CLOCK TICK - G2 CYCLINS TRANSCRIPTIONALLY ACTIVATE G2 CYCLINS AND REPRESS G1 CYCLINS [J].

AMON, A ;

TYERS, M ;

FUTCHER, B ;

NASMYTH, K .

CELL, 1993, 74 (06) :993-1007

[2] Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs [J].

Asano, M ;

Nevins, JR ;

Wharton, RP .

GENES & DEVELOPMENT, 1996, 10 (11) :1422-1432

[3] Analysis of a malsegregating mouse Y chromosome: evidence that the earliest cleavage divisions of the mammalian embryo are non-disjunction-prone [J].

Bean, CJ ;

Hunt, PA ;

Millie, EA ;

Hassold, TJ .

HUMAN MOLECULAR GENETICS, 2001, 10 (09) :963-972

[4]

Breeden L, 1996, CURR TOP MICROBIOL, V208, P95

[5] A genome-wide transcriptional analysis of the mitotic cell cycle [J].

Cho, RJ ;

Campbell, MJ ;

Winzeler, EA ;

Steinmetz, L ;

Conway, A ;

Wodicka, L ;

Wolfsberg, TG ;

Gabrielian, AE ;

Landsman, D ;

Lockhart, DJ ;

Davis, RW .

MOLECULAR CELL, 1998, 2 (01) :65-73

[6] Transcriptional regulation and function during the human cell cycle [J].

Cho, RJ ;

Huang, MX ;

Campbell, MJ ;

Dong, HL ;

Steinmetz, L ;

Sapinoso, L ;

Hampton, G ;

Elledge, SJ ;

Davis, RW ;

Lockhart, DJ .

NATURE GENETICS, 2001, 27 (01) :48-54

[7] Cdk1 triggers association of RNA polymerase to cell cycle promoters only after recruitment of the mediator by SBF (Publication with Expression of Concern) [J].

Cosma, MP ;

Panizza, S ;

Nasmyth, K .

MOLECULAR CELL, 2001, 7 (06) :1213-1220

[8] CDK activity antagonizes Whi5, an inhibitor of G1/S transcription in yeast [J].

Costanzo, M ;

Nishikawa, JL ;

Tang, XL ;

Millman, JS ;

Schub, O ;

Breitkreuz, K ;

Dewar, D ;

Rupes, I ;

Andrews, B ;

Tyers, M .

CELL, 2004, 117 (07) :899-913

[9] G1 transcription factors are differentially regulated in Saccharomyces cerevisiae by the Swi6-binding protein Stb1 [J].

Costanzo, M ;

Schub, O ;

Andrews, B .

MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (14) :5064-5077

[10] STARTING THE CELL-CYCLE - WHATS THE POINT [J].

CROSS, FR .

CURRENT OPINION IN CELL BIOLOGY, 1995, 7 (06) :790-797

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