Acute cyanide intoxication treated with a combination of hydroxycobalamin, sodium nitrite, and sodium thiosulfate

被引：19

作者：

Mannaioni, G ^{[1
]}

Vannacci, A ^{[1
]}

Marzocca, C ^{[1
]}

Zorn, AM ^{[1
]}

Peruzzi, S ^{[1
]}

Moroni, F ^{[1
]}

机构：

[1] Univ Florence, Dipartimento Farmacol Preclin & Clin, Med Toxicol Unit, I-50139 Florence, Italy

来源：

JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY | 2002年 / 40卷 / 02期

关键词：

cyanide; antidotes; methemoglobin; diabetes;

D O I：

10.1081/CLT-120004408

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

An 80-year-old diabetic patient was admitted to the hospital because of sudden unconsciousness and severe metabolic acidosis. His son reported the possibility of cyanide poisoning. Clinical data and the detection of cyanide in blood and gastric material confirmed this possibility. Supportive therapy and the following antidotes-sodium nitrite two doses 300 mg IV, sodium thiosulfate 3 g IV, and hydroxocobalamin 4 g in 24 hours-were administered immediately and the patient completely recovered in 48 hours. Our observations suggest that timely and appropriate use of antidotes for cyanide intoxication may prevent death, even in aged diabetic patients.

引用

页码：181 / 183

页数：3

共 11 条

[1] ELEVATED BLOOD CYANIDE CONCENTRATIONS IN VICTIMS OF SMOKE-INHALATION [J].