Cellular roles of DNA polymerase ζ and Rev1 protein

被引:181
作者
Lawrence, CW [1 ]
机构
[1] Univ Rochester, Sch Med & Dent, Dept Biochem & Biophys, Rochester, NY 14642 USA
关键词
DNA polymerase zeta; Rev1; protein; induced mutagenesis; translesion replication;
D O I
10.1016/S1568-7864(02)00038-1
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The majority of both spontaneous and DNA damage-induced mutations in eukaryotes result from replication processes in which DNA polymerase zeta (Polzeta) and Rev I protein (Rev1p) play major roles. Understanding these roles is likely to provide information relevant to the origin of genetic diseases, such as cancer, and may provide new insights for their prevention. DNA Polzeta also appears to be involved in the somatic hypermutability that occurs during development of the immune response. The results from a variety of genetic and enzymological investigations have started to delineate the cellular roles of these enzymes, but a number of important issues have not yet been resolved and much remains to be learned. Questions concerning the possible existence of other subunits to these enzymes, of their possible association with one another or with other proteins, of the nature of their enzymatic activities and of the relative roles played by these and other DNA polymerases in the bypass of different kinds of DNA damage, require further investigation. Finally, very little is known about the way these enzymes are regulated and brought into play when needed. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:425 / 435
页数:11
相关论文
共 77 条
[1]   FREQUENCY AND SPECTRUM OF MUTATIONS PRODUCED BY A SINGLE CIS-SYN THYMINE-THYMINE CYCLOBUTANE DIMER IN A SINGLE-STRANDED VECTOR [J].
BANERJEE, SK ;
CHRISTENSEN, RB ;
LAWRENCE, CW ;
LECLERC, JE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (21) :8141-8145
[2]   Analysis of damage tolerance pathways in Saccharomyces cerevisiae:: a requirement for Rev3 DNA polymerase in translesion synthesis [J].
Baynton, K ;
Bresson-Roy, A ;
Fuchs, RPP .
MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (02) :960-966
[3]   Distinct roles for Rev1p and Rev7p during translesion synthesis in Saccharomyces cerevisiae [J].
Baynton, K ;
Bresson-Roy, A ;
Fuchs, RPP .
MOLECULAR MICROBIOLOGY, 1999, 34 (01) :124-133
[4]   Disruption of mouse polymerase ζ (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro [J].
Bemark, M ;
Khamlichi, AA ;
Davies, SL ;
Neuberger, MS .
CURRENT BIOLOGY, 2000, 10 (19) :1213-1216
[5]  
BOOSALIS MS, 1987, J BIOL CHEM, V262, P14689
[6]   COMPILATION, ALIGNMENT, AND PHYLOGENETIC-RELATIONSHIPS OF DNA-POLYMERASES [J].
BRAITHWAITE, DK ;
ITO, J .
NUCLEIC ACIDS RESEARCH, 1993, 21 (04) :787-802
[7]   Genome sequence of the nematode C-elegans:: A platform for investigating biology [J].
不详 .
SCIENCE, 1998, 282 (5396) :2012-2018
[8]  
CASSIER C, 1980, GENETICS, V96, P841
[9]   ALLELISM BETWEEN PSO1-1 AND REV3-1 MUTANTS AND BETWEEN PSO2-1 AND SNM1 MUTANTS IN SACCHAROMYCES-CEREVISIAE [J].
CASSIERCHAUVAT, C ;
MOUSTACCHI, E .
CURRENT GENETICS, 1988, 13 (01) :37-40
[10]   MAD2B is an inhibitor of the anaphase-promoting complex [J].
Chen, J ;
Fang, GW .
GENES & DEVELOPMENT, 2001, 15 (14) :1765-1770