Fibroblast growth factor-1 inhibits medial smooth muscle cells apoptosis after balloon injury

被引:14
作者
Cuevas, P [1 ]
Carceller, F
Reimers, D
Giménez-Gallego
机构
[1] Hosp Ramon y Cajal, Dept Invest, Serv Histol, E-28034 Madrid, Spain
[2] CSIC, Madrid, Spain
关键词
fibroblast growth factor; rat carotid artery; angioplasty; apoptosis; vascular smooth muscle cells; bcl-X protein;
D O I
10.1080/01616412.2000.11741058
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We performed balloon injury in the rat common carotid artery and identified apoptosis of vascular smooth muscle cells (VSMCs) by in situ terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling, 2 h after injury. Balloon injury induces apoptosis and loss of bcl-X protein in the innermost layers of the media of the common carotid artery. Treatment with acidic fibroblast growth factor (aFGF, FGF-1) attenuated by 56% the balloon angioplasty-induced apoptosis. In addition, FGF-1 treatment also induces expression of the bcl-X anti-apoptotic protein in the same site of the media showing VSMC apoptosis. These data suggest that the anti-apoptotic effect of FGF in injured vascular wall was mediated by a bcl-X pathway and identified FGF as an important factor in vascular remodeling.
引用
收藏
页码:185 / 188
页数:4
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