Preventing surgery-induced NK cell dysfunction and cancer metastases with influenza vaccination

被引：24

作者：

Tai, Lee-Hwa ^{[1
]}

Zhang, Jiqing ^{[1
,2
,3
]}

Auer, Rebecca C. ^{[1
,4
,5
]}

机构：

[1] Ottawa Hosp, Res Inst, Ctr Innovat Canc Res, Ottawa, ON, Canada

[2] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON, Canada

[3] Shandong Univ, Hosp 2, Dept Neurosurg, Jinan, Shandong, Peoples R China

[4] Univ Ottawa, Dept Surg, Ottawa, ON, Canada

[5] Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON, Canada

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 11期

关键词：

cancer metastases; influenza vaccine; immunosuppression; natural killer cells; surgical stress; NATURAL-KILLER-CELLS; IMMUNOSUPPRESSION; DISEASE;

D O I：

10.4161/onci.26618

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Surgical resection is the mainstay of treatment for solid tumors, but the postoperative period is uniquely inclined to the formation of metastases, largely due to the suppression of natural killer (NK) cells. We found that preoperative influenza vaccination prevents postoperative NK-cell dysfunction, attenuating tumor dissemination in murine models and promoting the activation of NK cells in cancer patients.

引用

页数：3

共 10 条

[1]

Ben-Eliyahu S, 1999, INT J CANCER, V80, P880

[2]

Excisional surgery for cancer cure: therapy at a cost [J].

Coffey, JC ;

Wang, JH ;

Smith, MJF ;

Bouchier-Hayes, D ;

Cotter, TG ;

Redmond, HP .

LANCET ONCOLOGY, 2003, 4 (12) :760-768

[3]

PERIOPERATIVE IMMUNOMODULATION IN CANCER-SURGERY [J].

COLACCHIO, TA ;

YEAGER, MP ;

HILDEBRANDT, LW .

AMERICAN JOURNAL OF SURGERY, 1994, 167 (01) :174-179

[4]

Improving Postoperative Immune Status and Resistance to Cancer Metastasis A Combined Perioperative Approach of Immunostimulation and Prevention of Excessive Surgical Stress Responses [J].

Goldfarb, Yael ;

Sorski, Liat ;

Benish, Marganit ;

Levi, Ben ;

Melamed, Rivka ;

Ben-Eliyahu, Shamgar .

ANNALS OF SURGERY, 2011, 253 (04) :798-810

[5]

Distinct mechanisms of immunosuppression as a consequence of major surgery [J].

Hensler, T ;

Hecker, H ;

Heeg, K ;

Heidecke, CD ;

Bartels, H ;

Barthlen, W ;

Wagner, H ;

Siewert, JR ;

Holzmann, B .

INFECTION AND IMMUNITY, 1997, 65 (06) :2283-2291

[6]

Surgical trauma: hyperinflammation versus immunosuppression? [J].

Menger, MD ;

Vollmar, B .

LANGENBECKS ARCHIVES OF SURGERY, 2004, 389 (06) :475-484

[7]

Oosterling SJ, 2006, HISTOL HISTOPATHOL, V21, P753, DOI 10.14670/HH-21.753

[8]

Potential prophylactic measures against postoperative immunosuppression: Could they reduce recurrence rates in oncological patients? [J].

Shakhar, G ;

Ben-Eliyahu, S .

ANNALS OF SURGICAL ONCOLOGY, 2003, 10 (08) :972-992

[9]

Perioperative Influenza Vaccination Reduces Postoperative Metastatic Disease by Reversing Surgery-Induced Dysfunction in Natural Killer Cells [J].

Tai, Lee-Hwa ;

Zhang, Jiqing ;

Scott, Karen J. ;

de Souza, Christiano Tanese ;

Alkayyal, Almohanad A. ;

Ananth, Anu Abhirami ;

Sahi, Shalini ;

Adair, Robert A. ;

Mahmoud, Ahmad B. ;

Sad, Subash ;

Bell, John C. ;

Makrigiannis, Andrew P. ;

Melcher, Alan A. ;

Auer, Rebecca C. .

CLINICAL CANCER RESEARCH, 2013, 19 (18) :5104-5115

[10]

Preventing Postoperative Metastatic Disease by Inhibiting Surgery-Induced Dysfunction in Natural Killer Cells [J].

Tai, Lee-Hwa ;

de Souza, Christiano Tanese ;

Belanger, Simon ;

Ly, Lundi ;

Alkayyal, Almohanad A. ;

Zhang, Jiqing ;

Rintoul, Julia L. ;

Ananth, Abhirami A. ;

Lam, Tiffany ;

Breitbach, Caroline J. ;

Falls, Theresa J. ;

Kim, David H. ;

Bell, John C. ;

Makrigiannis, Andrew P. ;

Auer, Rebecca A. .

CANCER RESEARCH, 2013, 73 (01) :97-107

← 1 →