Riboflavin and migraine: the bridge over troubled mitochondria

被引：42

作者：

Colombo, Bruno ^{[1
]}

Saraceno, Lorenzo ^{[1
]}

Comi, Giancarlo ^{[1
]}

机构：

[1] Univ Vita Salute, Hosp San Raffaele, Dept Neurol, Headache Unit, I-20132 Milan, Italy

来源：

NEUROLOGICAL SCIENCES | 2014年 / 35卷

关键词：

Migraine; Mitochondria; Riboflavin; HIGH-DOSE RIBOFLAVIN; CONTROLLED-TRIAL; DOUBLE-BLIND; PROPHYLAXIS; HEADACHE; SPECTROSCOPY; DEFICIENCY; CHILDREN;

D O I：

10.1007/s10072-014-1755-z

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Brain energy metabolism has been found to be disturbed in migraine. A mitochondrial defect may reduce the threshold for migraine attacks both increasing neuronal excitability and leading migrainous brain to a hyper-responsiveness to triggering stimuli. Riboflavin, a major co-factor in oxidative metabolism, may overcome this impairment. RCT studies in adult confirmed that riboflavin is safe and probably effective in migraine prophylaxis, based on level B evidence. Improving brain energy metabolism may reduce the susceptibility to migraine when brain energy demand increases due to both physiological and biopsychological factors.

引用

页码：S141 / S144

页数：4

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