Cdc7 as a Potential New Target for Cancer Therapy

被引：18

作者：

Ito, Sayuri ^{[2
]}

Taniyami, Chika ^{[2
]}

Arai, Naoko

Masai, Hisao ^{[1
]}

机构：

[1] Tokyo Metropolitan Inst Med Sci, Genome Dynam Project, Bunkyo Ku, Tokyo 1138613, Japan

[2] SBI Biotech Co Ltd, Dept Res & Dev, Ginko Biomed Res Inst, Kawasaki, Kanagawa, Japan

来源：

DRUG NEWS & PERSPECTIVES | 2008年 / 21卷 / 09期

关键词：

D O I：

10.1358/dnp.2008.21.9.1290818

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cdc7 kinase plays crucial roles in firing of replication origins and in proper maintenance of replication forks, which are the sites of DNA replication. The inactivation of Cdc7 causes destabilization of replication forks leading to acute genomic instability and induces massive cell death preferentially in cancer cells. Thus, Cdc7 kinase may be a promising novel target for cancer therapy. Indeed, the first classes of Cdc7 inhibitors have been reported and have been shown to be effective in delaying tumor growth in animal models.

引用

页码：481 / 488

页数：8

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