Irritable bowel syndrome: A concise review of current treatment concepts

被引:44
作者
Wall, Geoffrey C. [1 ]
Bryant, Ginelle A. [1 ]
Bottenberg, Michelle M. [1 ]
Maki, Erik D. [1 ]
Miesner, Andrew R. [1 ]
机构
[1] Drake Univ, Coll Pharm, Dept Pharm Practice, Des Moines, IA 50311 USA
关键词
Irritable bowel syndrome; Probiotics; Rifaximin; Lubiprostone; Linaclotide; Peppermint oil; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; PEPPERMINT-OIL; CLINICAL-TRIAL; RANDOMIZED-TRIAL; PHARMACOLOGICAL-TREATMENT; HYOSCINE BUTYLBROMIDE; IMPROVES SYMPTOMS; ABDOMINAL-PAIN; PROBIOTIC USE;
D O I
10.3748/wjg.v20.i27.8796
中图分类号
R57 [消化系及腹部疾病];
学科分类号
100201 [内科学];
摘要
Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders causing patients to seek medical treatment. It is relatively resource intensive and the source of significant morbidity. Recent insights into the pathophysiology and treatment of IBS has given clinicians more options than ever to contend with this disorder. The purpose of our paper is to review older, "classic" treatments for IBS as well as newer agents and "alternative" therapies. We discuss the evidence base of these drugs and provide context to help develop appropriate treatment plans for IBS patients. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
引用
收藏
页码:8796 / 8806
页数:11
相关论文
共 74 条
[1]
Effect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome [J].
Andresen, Viola ;
Camilleri, Michael ;
Busciglio, Irene A. ;
Grudell, April ;
Burton, Duane ;
Mckinzie, Sanna ;
Foxx-Orenstein, Amy ;
Kurtz, Caroline B. ;
Sharma, Vineeta ;
Johnston, Jeffrey M. ;
Currie, Mark G. ;
Zinsmeister, Alan R. .
GASTROENTEROLOGY, 2007, 133 (03) :761-768
[2]
[Anonymous], 2013, LINZ PROD INF 2013
[3]
[Anonymous], 2011, POSTGRAD MED, V123, P122, DOI [10.3810/pgm.2011.05.2290, DOI 10.3810/PGM.2011.05.2290]
[4]
[Anonymous], 2012, GUIDANCE IND IRRITAB
[5]
[Anonymous], 2013, AM PROD INF 2013
[6]
A randomized, double-blind, placebo-controlled trial of polyethylene glycol effects on fasting and postprandial rectal sensitivity and symptoms in hypersensitive constipation-predominant irritable bowel syndrome [J].
Awad, R. A. ;
Camacho, S. .
COLORECTAL DISEASE, 2010, 12 (11) :1131-1138
[7]
Mechanisms of hypersensitivity in IBS and functional disorders [J].
Azpiroz, F. ;
Bouin, M. ;
Camilleri, M. ;
Mayer, E. A. ;
Poitras, P. ;
Serra, J. ;
Spiller, R. C. .
NEUROGASTROENTEROLOGY AND MOTILITY, 2007, 19 :62-88
[8]
Basseri Robert J, 2011, Gastroenterol Hepatol (N Y), V7, P455
[9]
Systematic review: the role of different types of fibre in the treatment of irritable bowel syndrome [J].
Bijkerk, CJ ;
Muris, JWM ;
Knottnerus, JA ;
Hoes, AW ;
De Wit, NJ .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2004, 19 (03) :245-251
[10]
Effect of Red Pepper on Symptoms of Irritable Bowel Syndrome: Preliminary Study [J].
Bortolotti, M. ;
Porta, S. .
DIGESTIVE DISEASES AND SCIENCES, 2011, 56 (11) :3288-3295