Is benign rolandic epilepsy genetically determined?

被引：38

作者：

Vadlamudi, L

Harvey, AS

Connellan, MM

Milne, RL

Hopper, JL

Scheffer, IE

Berkovic, SF

机构：

[1] Univ Melbourne, Austin Hlth, Dept Med Neurol, Epilepsy Res Ctr, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Ctr Genet Epidemiol, Melbourne, Vic, Australia

来源：

ANNALS OF NEUROLOGY | 2004年 / 56卷 / 01期

关键词：

D O I：

10.1002/ana.20153

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Benign rolandic epilepsy (BRE) is considered to be a genetically determined idiopathic partial epilepsy. We studied twins with BRE and compared the concordance with a twin sample of idiopathic generalized epilepsy (IGE). All eight BRE pairs (six monozygous [MZ], two dizygous [DZ]) were discordant. MZ pairwise concordance was 0 (95% confidence interval [CI], 0-0.4) for BRE compared with 0.7 (95% CI, 0.5-0.9) for 26 IGE MZ pairs. Our data suggest that conventional genetic influences in BRE are considerably less than for IGE, and other mechanisms need to be explored.

引用

页码：129 / 132

页数：4

共 17 条

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