Vitamin D Status and Its Relationship with Body Composition, Bone Mineral Density and Fracture Risk in Urban Central South Chinese Postmenopausal Women

被引:49
作者
Li, Shuang [1 ]
Ou, Yangna [2 ]
Zhang, Hongbing [1 ]
Zhang, Zhimin [1 ]
Zhou, Houde [1 ]
Liu, Lihong [3 ]
Sheng, Zhifeng [1 ]
Liao, Eryuan [1 ]
机构
[1] Cent S Univ, Xiangya Hosp 2, Inst Metab & Endocrinol, Changsha 410011, Hunan, Peoples R China
[2] Cent S Univ, Xiangya Hosp 2, Dept Hosp Infect Management, Changsha 410011, Hunan, Peoples R China
[3] Cent S Univ, Xiangya Hosp 2, Dept Orthoped, Changsha 410011, Hunan, Peoples R China
基金
中国国家自然科学基金;
关键词
Bone mineral density; Chinese women; FRAX; Vitamin D; SERUM 25-HYDROXYVITAMIN D; D DEFICIENCY; ELDERLY-WOMEN; PARATHYROID FUNCTION; SUNLIGHT EXPOSURE; HYPOVITAMINOSIS-D; D INADEQUACY; OSTEOPOROSIS; TURNOVER; PREVALENCE;
D O I
10.1159/000358340
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Aims: This study was designed to assess vitamin D (25(OH)D) status and its relationship with bone mineral density (BMD) and fracture risk, which was determined using the FRAX algorithm, among postmenopausal central south Chinese women, and to identify the risk factors for vitamin D deficiency and osteoporosis. Methods: This cross-sectional study involved 578 healthy postmenopausal central south Chinese women. Fat mass and BMD at lumbar spine (L1-L4), femur neck and total hip were measured with dual X-ray absorptiometry. Serum levels of 25(OH)D, parathyroid hormone and creatinine were measured. The 10-year probabilities of hip and major osteoporotic fracture were calculated by the FRAX model. Results: Approximately 72.1% women were vitamin D deficient (25(OH)D <50 nmol/l). Serum 25(OH)D levels did not correlate with body mass index (BMI), fat mass and weight. They positively correlated with all BMDs (p < 0.05) and negatively correlated with both 10-year fracture probabilities (p < 0.05). BMI <= 19 and age >= 65 years were risk factors for osteoporosis at all sites. Conclusions: Vitamin D deficiency was prevalent among postmenopausal central south Chinese women. Serum 25(OH)D levels were correlated with all BMDs and negatively correlated with both 10-year fracture probabilities. (C) 2014 S. Karger AG, Basel
引用
收藏
页码:13 / 19
页数:7
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