Phosphoinositide signaling plays a key role in cytokinesis

被引:86
作者
Janetopoulos, Chris
Devreotes, Peter [1 ]
机构
[1] Johns Hopkins Univ, Sch Med, Dept Cell Biol, Baltimore, MD 21205 USA
[2] Vanderbilt Univ, Dept Biol Sci, Nashville, TN 37232 USA
关键词
D O I
10.1083/jcb.200603156
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
To perform the vital functions of motility and division, cells must undergo dramatic shifts in cell polarity. Recent evidence suggests that polarized distributions of phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, which are clearly important for regulating cell morphology during migration, also play an important role during the final event in cell division, which is cytokinesis. Thus, there is a critical interplay between the membrane phosphoinositides and the cytoskeletal cortex that regulates the complex series of cell shape changes that accompany these two processes.
引用
收藏
页码:485 / 490
页数:6
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