Reactive oxygen species in cancer cells: Live by the sword, die by the sword

被引:1039
作者
Schumacker, Paul T.
机构
关键词
D O I
10.1016/j.ccr.2006.08.015
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Reactive oxygen species and tumor biology are intertwined in a complex web, making it difficult to understand which came first, whether oxidants are required for tumor cell growth, and whether oxidant stress can be exploited therapeutically. Evidence suggests that transformed cells use ROS signals to drive proliferation and other events required for tumor progression. This confers a state of increased basal oxidative stress, making them vulnerable to chemotherapeutic agents that further augment ROS generation or that weaken antioxidant defenses of the cell. In this respect, it appears that tumor cells may die by the same systems they require.
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页码:175 / 176
页数:2
相关论文
共 8 条
[1]   Synergistic effect of histone deacetylase inhibitors FK228 and m-carboxycinnamic acid bis-hydroxamide with proteasome inhibitors PSI and PS-341 against gastrointestinal adenocarcinoma cells [J].
Adachi, M ;
Zhang, YB ;
Zhao, XD ;
Minami, T ;
Kawamura, R ;
Hinoda, Y ;
Imai, K .
CLINICAL CANCER RESEARCH, 2004, 10 (11) :3853-3862
[2]   Distinct roles of thioredoxin in the cytoplasm and in the nucleus -: A two-step mechanism of redox regulation of transcription factor NF-κB [J].
Hirota, K ;
Murata, M ;
Sachi, Y ;
Nakamura, H ;
Takeuchi, J ;
Mori, K ;
Yodoi, J .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (39) :27891-27897
[3]   Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines [J].
Lecane, PS ;
Karaman, MW ;
Sirisawad, M ;
Naumovski, L ;
Miller, RA ;
Hacia, JG ;
Magda, D .
CANCER RESEARCH, 2005, 65 (24) :11676-11688
[4]   The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status [J].
Pérez-Galán, P ;
Roué, G ;
Villamor, N ;
Montserrat, E ;
Campo, E ;
Colomer, D .
BLOOD, 2006, 107 (01) :257-264
[5]   mtDNA mutations increase tumorigenicity in prostate cancer [J].
Petros, JA ;
Baumann, AK ;
Ruiz-Pesini, E ;
Amin, MB ;
Sun, CQ ;
Hall, J ;
Lim, S ;
Issa, MM ;
Flanders, WD ;
Hosseini, SH ;
Marshall, FF ;
Wallace, DC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (03) :719-724
[6]  
SZATROWSKI TP, 1991, CANCER RES, V51, P794
[7]   A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: A dawn for evolutionary medicine [J].
Wallace, DC .
ANNUAL REVIEW OF GENETICS, 2005, 39 :359-407
[8]   Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells [J].
Yoo, MH ;
Xu, XM ;
Carlson, BA ;
Gladyshev, VN ;
Hatfield, DL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (19) :13005-13008