Effect of the free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5one (MCI-186), on hypoxia-ischemia-induced brain injury in neonatal rats

被引：57

作者：

Ikeda, T ^{[1
]}

Xia, YX ^{[1
]}

Kaneko, M ^{[1
]}

Sameshima, H ^{[1
]}

Ikenoue, T ^{[1
]}

机构：

[1] Miyazaki Med Coll, Dept Obstet & Gynecol, Kiyotake, Miyazaki 88916, Japan

来源：

NEUROSCIENCE LETTERS | 2002年 / 329卷 / 01期

关键词：

neonatal rat; hypoxia-ischemia; oxidative stress; free radical scavenger; 3-methyl-1-phenyl-2-pyrazolin-5-one;

D O I：

10.1016/S0304-3940(02)00573-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The free radical scavenger 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), which has been approved in Japan for use in patients with cerebral infarction, was used to treat ischemic-hypoxic brain damage in neonatal rats. Seven-day-old rat pups were subjected to a modified Levine procedure, then given either vehicle or MCI-186 (at one of three dosage levels: 3, 6, or 9 mg/kg), and the extent of brain damage was evaluated either 24 h or 7 days later. The administration of MCI-186 significantly attenuated damage, in a dose-dependent manner. These results indicate that MCI-186 is a promising candidate for the treatment of neonatal hypoxic-ischemic encephalopathy. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：33 / 36

页数：4

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