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Rapamycin inhibits mTORC1, but not completely
被引：214
作者：
Thoreen, Carson C.
[1
]
Sabatini, David M.
[1
]
机构：
[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
来源：
关键词：
mTORC1;
mTOR;
raptor;
torin1;
rapamycin resistance;
rapamycin;
autophagy;
4E-BP1;
cap-dependent translation;
D O I：
10.4161/auto.5.5.8504
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ;
090102 ;
摘要：
Rapamycin is widely used as a complete inhibitor of the mTORC1 nutrient-sensitive signaling complex. Using a novel ATP-competitive inhibitor named Torin1, we have found that many mTORC1 functions that regulate cap-dependent translation and autophagy are resistant to inhibition by rapamycin.
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页码：725 / 726
页数：2
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