Optical Coherence Tomographic Results at Six-Month Follow-Up Evaluation of the CATANIA Coronary Stent System With NanoThin Polyzene-F Surface Modification (from the Assessment of The LAtest Non-Thrombogenic Angioplasty Stent [ATLANTA] Trial)

被引:16
作者
La Manna, Alessio [1 ]
Capodanno, Davide [1 ]
Cera, Maria [2 ]
Di Salvo, Maria Elena [1 ]
Sacchetta, Giorgio [1 ]
Corcos, Thierry [3 ]
Prati, Francesco [2 ]
Tamburino, Corrado [1 ]
机构
[1] Univ Catania, Ferrarotto Hosp, Dept Cardiol, Catania, Italy
[2] San Giovanni Hosp, Rome, Italy
[3] Clin Turin, Dept Intervent Cardiol, Paris, France
关键词
SIROLIMUS-ELUTING STENT; NEOINTIMAL COVERAGE; IMPLANTATION; THROMBOSIS;
D O I
10.1016/j.amjcard.2009.01.378
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Drug-eluting stents were devised as an answer to restenosis, but research has shown that the eluting drug can interfere with the blood vessel's healing process, thus increasing the risk of stent thrombosis. A stent coated with the new proprietary polymer Polyzene-F, is a novel technical solution that promises to decrease in-stent restenosis and tackle the risk of thrombosis. Fifty-five patients were enrolled in the first clinical human study (ATLANTA registry), addressing the short-term follow-up results of the CATANIA stent with Polyzene-F. As a part of the study protocol, 15 patients were randomly assigned to optical coherence tomographic (OCT) examination at 6-month follow-up. Optical coherence tomograms were obtained using a Lightlab M2 system with a motorized pull-back at 2.0 mm/s. OCT images were acquired at 15.6 firames/s. A total of 1,904 cross-sectional images with 19,028 struts were analyzed. The rate of covered struts was 99.5%, whereas malapposed struts accounted for 0.15%. Area measurements were performed in 476 cross sections. Neointimal hyperplasia (NIH) area and percent NIH area were 3.2 +/- 1.4 mm(2) and 38 +/- 17%, respectively. Percent NIH area was comparable between diabetics and nondiabetics. Qualitative assessment of OCT images demonstrated neither occurrence of stent fractures nor thrombus. In conclusion, OCT assessment-of the Polyzene-F-covered stent at follow-up showed a small percentage of neointima. Also, almost complete stent strut coverage was revealed by optical coherence tomography. These figures indicate that the CATANIA stent with Polyzene-F is a promising solution for decreasing late stent restenosis and preventing thrombosis. (C) 2009 Elsevier Inc. All rights reserved. (Am J Cardiol 2009;103:1551-1555)
引用
收藏
页码:1551 / 1555
页数:5
相关论文
共 14 条
[1]   Early and late coronary stent thrombosis of sirolimus-eluting and paclitaxel-eluting stents in routine clinical practice:: data from a large two-institutional cohort study [J].
Daemen, Joost ;
Wenaweser, Peter ;
Tsuchida, Keiichi ;
Abrecht, Linda ;
Sophia, Vaina ;
Morger, Cyrill ;
Kukreja, Neville ;
Jueni, Peter ;
Sianos, Georgios ;
Hellige, Gerrit ;
van Domburg, Ron T. ;
Hess, Otto M. ;
Boersma, Eric ;
Meier, Bernhard ;
Windecker, Stephan ;
Serruys, Patrick W. .
LANCET, 2007, 369 (9562) :667-678
[2]   Optical Coherence Tomography A New Tool to Detect Tissue Coverage in Drug-Eluting Stents [J].
Di Mario, Carlo ;
Barlis, Peter .
JACC-CARDIOVASCULAR INTERVENTIONS, 2008, 1 (02) :174-175
[3]   Pathological correlates of late drug-eluting stent thrombosis - Strut coverage as a marker of endothelialization [J].
Finn, Aloke V. ;
Joner, Michael ;
Nakazawa, Gaku ;
Kolodgie, Frank ;
Newell, John ;
John, Mike C. ;
Gold, Herman K. ;
Virmani, Renu .
CIRCULATION, 2007, 115 (18) :2435-2441
[4]   Neointimal coverage of sirolimus-eluting stents at 6-month follow-up: evaluated by optical coherence tomography [J].
Matsumoto, Daisuke ;
Shite, Junya ;
Shinke, Toshiro ;
Otake, Hiromasa ;
Tanino, Yusuke ;
Ogasawara, Daisuke ;
Sawada, Takahiro ;
Paredes, Oscar Luis ;
Hirata, Ken-ichi ;
Yokoyama, Mitsuhiro .
EUROPEAN HEART JOURNAL, 2007, 28 (08) :961-967
[5]   Does optical coherence tomography identify arterial healing after stenting? An in vivo comparison with histology, in a rabbit carotid model [J].
Prati, F. ;
Zimarino, M. ;
Stabile, E. ;
Pizzicannella, G. ;
Fouad, T. ;
Rabozzi, R. ;
Filippini, A. ;
Pizzicannella, J. ;
Cera, M. ;
De Caterina, R. .
HEART, 2008, 94 (02) :217-221
[6]  
Prati Francesco, 2007, EuroIntervention, V3, P365, DOI 10.4244/EIJV3I3A66
[7]   From bench to bedside - A novel technique of acquiring OCT images [J].
Prati, Francesco ;
Cera, Maria ;
Ramazzotti, Vito ;
Imola, Fabrizio ;
Giudice, Rocco ;
Giudice, Marco ;
De Propris, Silvia ;
Albertucci, Mario .
CIRCULATION JOURNAL, 2008, 72 (05) :839-843
[8]   A new polymer concept for coating of vascular stents using PTFEP (poly(bis(trifluoroethoxy)phosphazene) to reduce thrombogenicity and late in-stent stenosis [J].
Richter, GM ;
Stampfl, U ;
Stampfl, S ;
Rehnitz, C ;
Holler, S ;
Schnabel, P ;
Grunze, M .
INVESTIGATIVE RADIOLOGY, 2005, 40 (04) :210-218
[9]   In Vivo Comparison Between Optical Coherence Tomography and Intravascular Ultrasound for Detecting Small Degrees of In-Stent Neointima After Stent Implantation [J].
Suzuki, Yoriyasu ;
Ikeno, Fumiaki ;
Koizumi, Tomomi ;
Tio, Fermin ;
Yeung, Alan C. ;
Yock, Paul G. ;
Fitzgerald, Peter J. ;
Fearon, William F. .
JACC-CARDIOVASCULAR INTERVENTIONS, 2008, 1 (02) :168-173
[10]   Evaluation by optical coherence tomography of neointimal coverage of sirolimus-eluting stent three months after implantation [J].
Takano, Masamichi ;
Inami, Shigenobu ;
Jang, Ik-Kyung ;
Yamamoto, Masanori ;
Murakami, Daisuke ;
Seimiya, Koji ;
Ohba, Takayoshi ;
Mizuno, Kyoichi .
AMERICAN JOURNAL OF CARDIOLOGY, 2007, 99 (08) :1033-1038